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Wicher C, Biewald G-A Left-ventricular dysfunction, heart vagus influences and angiotensin II effects after doxorubicin perfusion in isolated rat hearts Journal of Clinical and Basic Cardiology 1999; 2 (2): 259-266 PDF Summary Overview
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Figure/Graphic 1A-B: Angiotensin II - Vagusstimulation Effects of angiotensin II on time course of left-ventricular pressure (LVP) and on vagus stimulation effect, recorded in isolated rat hearts (modified Langendorff preparation). Time periods of vagus stimulation (right N. vagus, 10 Hz, 10 V, 10 s stimulation period) are marked by horizontal bars. A: control recording before AII application, B: recording 5 min after addition of 2 micromol/L AII to perfusion solution. Note clear reductions in heart rate and systolic pressure caused by vagus timulation during Tyrode perfusion (A). AII had direct positive chronotropic and inotropic effects and inhibited the vagus stimulation effects (B). |
Figure/Graphic 1A-B: Angiotensin II - Vagusstimulation
Effects of angiotensin II on time course of left-ventricular pressure (LVP) and on vagus stimulation effect, recorded in isolated rat hearts (modified Langendorff preparation). Time periods of vagus stimulation (right N. vagus, 10 Hz, 10 V, 10 s stimulation period) are marked by horizontal bars. A: control recording before AII application, B: recording 5 min after addition of 2 micromol/L AII to perfusion solution. Note clear reductions in heart rate and systolic pressure caused by vagus timulation during Tyrode perfusion (A). AII had direct positive chronotropic and inotropic effects and inhibited the vagus stimulation effects (B). |