Abbildung 21: Kardiovaskuläres Risiko - Blutdrucksenkung
A meta-analysis of 61 prospective, observational studies has shown that a 10 mmHg lower S BP is associated over the long term with a 40% lower risk of stroke death and a 30% lower risk of death from ischaemic heart disease (IHD) or other vascular causes.1 Even a small, 2 mmHg fall in mean S BP was associated with large reductions in premature deaths and disabling strokes.1 There was no evidence of a J-curve (i.e. a threshold of reduction beyond which risk begins to increase).1 The reduction in risk associated with a given reduction in mean blood pressure is approximately constant down to at least an SBP of 115 mmHg and a DBP of 75 mmHg – well beyond what is normally achieved.1 The reduction in risk holds for all age groups assessed from 40 up to 89 years old.1 1. Lewington S, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903–1913.