Abbildung 14: Umstellung Avonex - Rebif
'n’ of 188 reflects number of patients in post transition group (223) who had scans performed – not all patients had scans during EVIDENCE and a number of scans are missing due to errors at site in terms of when scans were to be done. Y-axis shows either relapse rate, T2 count per patient per scan or the proportion of scans active per patient or proportion of patients with no active scans – values are means (median for T2 lesions and % T2 active scans are both 0). The ns difference for % with no T2 activity likely reflects 2 issues – based on dose titration, switch patients are still on low dose therapy for first month and any single new lesion renders the patient active for the entire interval. Secondly, the post-T interval is on average 8 months compared to 6 months or less for the pre-T scan. Otherwise, data shows there is a substantial and immediate effect of switching from 30 qw to 44 tiw.