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Atwa HA, Shora H  
Glycemic Control Could Reverse Subclinical Atherosclerotic Changes and Normal Adiponectin Levels in Lean Type-1 Diabetic Children

Journal of Clinical and Basic Cardiology 2011; 14 (1-4): 3-6

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Fig. 1: Adiponectin - cIMT

Keywords: adiponectincarotid intima media thicknessglycemic controlglydemic controlsubclinical atherosclerosistype-1 diabetes

Adiponectin is an anti-inflammatory, antiatherogenic, and insulin-sensitizing hormone. It inhibits neointimal media thickening and vascular smooth muscle cell proliferation. This study aimed at delineating the relation between glycemic control and adiponectin levels and its impact on carotid intima media thickness (cIMT) in lean, newly diagnosed type-1 diabetic children. 46 diabetic children were examined, their mean age was 11.59 3.64 years (mean duration of diabetes 2.89 1.15 years, mean BMI 20.86 3.94, mean annual HbA1c 7.7 1.5). 46 healthy control subjects matched in age, sex, and BMI were enrolled in this cross-sectional study at the Suez Canal University Hospital pediatric outpatient clinic in Ismailia. All children had normal blood pressure for age and sex, normal lipid profile and normomalbuminuria. Adiponectin and HbA1c were measured, carotid intima media thickness was assessed. Adiponectin levels were significantly lower in children with type-1 diabetes mellitus (DM1; 10.1 1.57 mg) compared with controls (11.23 1.14 mg; p = 0.02). Children with DM1 had a significantly higher cIMT (0.55 0.06 mm) than controls (0.43 0.04 mm; p = 0.00). Adiponectin levels correlated negatively with cIMT (p = 0.01). Adiponectin levels showed no significant difference in children with good metabolic control (average annual HBA1c < 7 %; 11.51 0.45 mg) compared to the control group (11.23 1.14 mg; p = 0.15). Adiponectin was significantly higher (11.51 0.45 mg) and cIMT was significantly lower (0.45 0.03 mm) in children with good metabolic control than in those with poor metabolic control (9.43 1.38 mg; 0.57 0.05 mm). From the results it can be concluded that glycemic control may have a crucial impact on preventing atherosclerotic changes in type-1 diabetic children with a short duration of diabetes. Diabetic children with good metabolic control and a short duration of diabetes had no significant difference in adiponectin levels compared to healthy children.
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