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Nolte J, Engel W  
Artificial Sperm

Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 66-71

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Keywords: Andrologiein vitro spermatogenesisinfertilitystem cell

Spermatogenesis is a complex mechanism that is controlled by an extensive network of hormonal activities within an outstanding organized and structured tissue. Spermatogonial stem cells (SSCs) provide the basis of lifelong spermatogenesis by renewing the pool of SSCs balanced with differentiation into spermatogonia which will than give rise to spermatozoa. The process of spermatogenesis has been investigated by scientists all over the world for many decades. To understand the mechanisms leading to the development of haploid gametes originating from a stem cell, is at the same time fascinating and important since this is the process that leads to the next generation. To have a tool for the investigation of this outstanding process, the establishment of robust protocols for the in vitro generation and differentiation of spermatozoa is necessary. However, it is not only important for understanding the basics of spermatogenesis but also to create ex vivo systems for the generation of artificial sperm starting from immature germ cells from infertile patients.
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