|Schmid S et al.|
Meilensteine in der Entwicklung des aktuellen Behandlungskonzeptes für niedriggradige Gliome // Cornerstones in the development of treatment concept of low grade gliomas
Journal für Neurologie, Neurochirurgie und Psychiatrie 2018; 19 (1): 14-19
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Keywords: Chemotherapie, Neurochirurgie, Neuromonitoring, niedriggradiges Gliom, Strahlentherapie, chemotherapy, low-grade glioma, Neuromonitoring, neurosurgery, radiotherapy
A major challenge in the treatment of Low Grade Gliomas (LGG) is decision making at what time which treatment should be offered. Treatment options include a wide range from wait-and-see concept through biopsy with or without consecutive irradiation (and chemotherapy) towards maximum surgical resection.
Algorithms regarding decision making were continuously developed forward throughout the last years. Decisive variables are: age of the patients, clinical appearance and general health status, localization and size of the tumor, appearance in MRI and changes throughout follow-up investigations, and both histopathological and molecularpathological characteristics of the tumor. Progress in the treatment of LGG is mainly based on the currently improving surgery techniques including neuro-navigation, neuro-monitoring and awake-surgery, further on improvements in radiation treatment and recent developments in chemotherapy and targeted therapy, respectively.
This manuscript presents a retrospective analysis of patients with histologically verified LGG who have been treated between May 2006 and September 2016 at our department in order to outline which variables mainly contributed in the development of the treatment concept up to now.
Kurzfassung: Eine große Herausforderung im
Behandlungskonzept für niedriggradige Gliome (Low Grade Gliomas – LGG) ist die Entscheidungsfindung, wann welche therapeutischen Schritte gesetzt werden. Das Spektrum
erstreckt sich von einem Wait-and-See-Procedere über Biopsie mit oder ohne anschließender Radiatio (und Chemotherapie) bis hin zur Maximal-Resektion.