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Wieacker P  
Genetic Aspects of Premature Ovarian Failure

Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2009; 6 (1): 17-18

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Abb. 1: Hypergonadotropic hypogonadism



Keywords: ChromosomenaberrationGenmutationHumangenetikPOFchromosome aberrationgene mutationpremature ovarian failure

Premature ovarian failure (POF) is characterized by the combination of amenorrhea before age 40 years and hypergonadotropic hypogonadism. The prevalence is approximately 1 %. Genetic causes of POF include chromosome aberrations and monogenic defects. Furthermore, polygenic-multifactorial inheritance can be assumed in a subset of cases.
 
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