1.
Xu S;
Heimberger AB
Emerging Immune Therapeutics Targeting Glioblastoma-Mediated Immune Suppression: Dark Before the Dawn
Glioblastoma
European Association of NeuroOncology Magazine 2013; 3 (1): 15-22
Schema demonstrating immune activation and the role of
immune suppression and checkpoints. Glioblastoma exerts profound
immunosuppressive effects via multiple, redundant mechanisms, including
the TGF-β/VEGF signalling pathway, IL-2Rα/CD25-mediated IL-
2 deprivation, CTLA-4/PD-1/PD-L1 immune checkpoint interaction,
STAT3 activation, as well as by IDO/Arg-1 enzymatic suppression. All of
these mechanisms have been investigated as potential therapeutic targets
for glioblastoma treatment in various clinical and preclinical trials.
Keywords:
glioblastoma,
scheme
Suche Medizinische Publikationen
Suche Abbildungen und Grafiken
Medizinprodukte - Labortechnik
Antidotarium (Stand 2012)
Phytokodex (Stand 2012)
Fachbücher
Patientenliteratur