Figure 1: Morphologic correlates of CIPN. The DRGs can be the target of cumulative
neurotoxicity as in platinum compounds. Axons, rarely the myelin, can be damaged.
At the neuromuscular transmission site (NMT), the acute toxicity of oxaliplatin occurs.
Unmyelinated fibers and terminal nerve arbors are the sites of acute taxane
toxicity. An additional spinal mechanism at the alpha-2-delta-Typ1 subunit in neuropathic
pain is assumed.