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Grisold W, Oberndorfer S, Windebank AJ Chemotherapy and Polyneuropathies European Association of NeuroOncology Magazine 2012; 2 (1): 25-36 PDF Summary Overview
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Figure/Graphic 1: CIPN Morphologic correlates of CIPN. The DRGs can be the target of cumulative neurotoxicity as in platinum compounds. Axons, rarely the myelin, can be damaged. At the neuromuscular transmission site (NMT), the acute toxicity of oxaliplatin occurs. Unmyelinated fibers and terminal nerve arbors are the sites of acute taxane toxicity. An additional spinal mechanism at the alpha-2-delta-Typ1 subunit in neuropathic pain is assumed. |
Figure/Graphic 1: CIPN
Morphologic correlates of CIPN. The DRGs can be the target of cumulative neurotoxicity as in platinum compounds. Axons, rarely the myelin, can be damaged. At the neuromuscular transmission site (NMT), the acute toxicity of oxaliplatin occurs. Unmyelinated fibers and terminal nerve arbors are the sites of acute taxane toxicity. An additional spinal mechanism at the alpha-2-delta-Typ1 subunit in neuropathic pain is assumed. |