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Tamse CT, Lu X, Mortel EG, Cabrales E, Feng W, Schaefer S The Peripheral Benzodiazepine Receptor Modulates Ca2+Transport through the VDAC in Rat Heart Mitochondria Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 24-29 PDF Summary Overview
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Figure/Graphic 3: Calcium release Rate of calcium release (AU/sec) from isolated mitochondria as indicated by an increase in APIII absorbance signal following calcium loading in the absence and presence of CsA under different hemin concentrations (n = 7). There was no calcium release under control conditions in the absence of hemin. Calcium release was significantly greater than control in all experiments using hemin 2.5–10 μM with or without CsA (p < 0.01). In addition, calcium release was greater without CsA than with CsA at hemin 5 and 10 μM (*p < 0.05). |
Figure/Graphic 3: Calcium release
Rate of calcium release (AU/sec) from isolated mitochondria as indicated by an increase in APIII absorbance signal following calcium loading in the absence and presence of CsA under different hemin concentrations (n = 7). There was no calcium release under control conditions in the absence of hemin. Calcium release was significantly greater than control in all experiments using hemin 2.5–10 μM with or without CsA (p < 0.01). In addition, calcium release was greater without CsA than with CsA at hemin 5 and 10 μM (*p < 0.05). |