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Tamse CT, Lu X, Mortel EG, Cabrales E, Feng W, Schaefer S The Peripheral Benzodiazepine Receptor Modulates Ca2+Transport through the VDAC in Rat Heart Mitochondria Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 24-29 PDF Summary Overview
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Figure/Graphic 5: VDAC-PBR-ANT Current amplitude histograms of a VDAC-PBR-ANT channel complex reconstituted in lipid bilayer as exposure to defined concentrations of hemin. A the holding potential of –40 mV (on trans), VDAC-PBR-ANT stayed more frequently at maximal open state. Addition of 2.5, 5 and 10 μM hemin in the cis chamber promoted reduced current amplitudes to a lower and eventually zero value. |
Figure/Graphic 5: VDAC-PBR-ANT
Current amplitude histograms of a VDAC-PBR-ANT channel complex reconstituted in lipid bilayer as exposure to defined concentrations of hemin. A the holding potential of –40 mV (on trans), VDAC-PBR-ANT stayed more frequently at maximal open state. Addition of 2.5, 5 and 10 μM hemin in the cis chamber promoted reduced current amplitudes to a lower and eventually zero value. |