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Gasser R, Roessl U, Holzwart E, Ablasser K, Friehs I, Lewinski D, Pieske B, Mächler H, Trantiner-Yates A, Tscheliessnig KH, Mangge H, Gasser S Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters Journal of Clinical and Basic Cardiology 2009; 12 (1-4): 11-17 PDF Summary Overview
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Figure/Graphic 1: Real-time PCR Results from real-time PCR measurements of 72 experiments (n = 12 in each group; o2ko = well-oxygenated, no ischemia, no drug; n2ko = experimental ischemia, no drug; o2at = well-oxygenated, no ischemia, atenolol present; n2at = experimental ischemia, atenolol present; o2neb = well-oxygenated, nebivolol present; n2neb = experimental ischemia, nebivolol present). It can be seen that during experimental ischemia, there is an up-regulation of GLUT1 expression, however, not statistically significant. This confirms earlier data by our group. While there is no significant regulation with and without the influence of beta blockers during myocardial ischemia either, there is, however, a significant difference between the expression of GLUT1 in well-oxygenized preparations with (0.87 ± 0.02) and without nebivolol (0.62 ± 0.02; ± SEM; p ≤ 0.05). Similarly, atenolol led to an increase of GLUT1 expression in welloxygenated preparations compared to controls: 1.18 ± 0.08 and 0.62 ± 0.02, respectively (+ SEM; p < 0.05) |
Figure/Graphic 1: Real-time PCR
Results from real-time PCR measurements of 72 experiments (n = 12 in each group; o2ko = well-oxygenated, no ischemia, no drug; n2ko = experimental ischemia, no drug; o2at = well-oxygenated, no ischemia, atenolol present; n2at = experimental ischemia, atenolol present; o2neb = well-oxygenated, nebivolol present; n2neb = experimental ischemia, nebivolol present). It can be seen that during experimental ischemia, there is an up-regulation of GLUT1 expression, however, not statistically significant. This confirms earlier data by our group. While there is no significant regulation with and without the influence of beta blockers during myocardial ischemia either, there is, however, a significant difference between the expression of GLUT1 in well-oxygenized preparations with (0.87 ± 0.02) and without nebivolol (0.62 ± 0.02; ± SEM; p ≤ 0.05). Similarly, atenolol led to an increase of GLUT1 expression in welloxygenated preparations compared to controls: 1.18 ± 0.08 and 0.62 ± 0.02, respectively (+ SEM; p < 0.05) |