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Holzwart E, Gasser S, Roessl U, Buehner A, Ablasser K, Friehs I, Pieske B, Mächler H, Yates A, Tscheliessnig KH, Mangge H, Porta S, Gasser R Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium Journal of Clinical and Basic Cardiology 2010; 13 (1-4): 12-18 PDF Summary Overview
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Figure/Graphic 1: Gene expression Example of differential regulation of gene expression by atenolol and nebivolol in well-oxygenized preparations: one can see that numerous biochemical processes are affected by nebivolol but not by atenolol. For example, many processes involved in contraction, lipid metabolism, and proliferation are down-regulated by nebivolol only (not by atenolol). Reducing lipid metabolism in exchange for an increased carbohydrate metabolism may render the heart less vulnerable to O2 deficit or ischemia. |
Figure/Graphic 1: Gene expression
Example of differential regulation of gene expression by atenolol and nebivolol in well-oxygenized preparations: one can see that numerous biochemical processes are affected by nebivolol but not by atenolol. For example, many processes involved in contraction, lipid metabolism, and proliferation are down-regulated by nebivolol only (not by atenolol). Reducing lipid metabolism in exchange for an increased carbohydrate metabolism may render the heart less vulnerable to O2 deficit or ischemia. |