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Holzwart E, Gasser S, Roessl U, Buehner A, Ablasser K, Friehs I, Pieske B, Mächler H, Yates A, Tscheliessnig KH, Mangge H, Porta S, Gasser R
Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium
Journal of Clinical and Basic Cardiology 2010; 13 (1-4): 12-18

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Fig. 1: Gene expression Fig. 2: Gene expression This Image - Fig. 3: PDK Fig. 4: PCR - PDK
Figure/Graphic 3: PDK
In this figure, the results from microarray measurements of PDK experiments are illustrated. Pooled DNA data: Control experiments: Owo: pool control, well-oxygenated, no ischemia, no drug; Nwo: pool experimental ischemia, no drug; Atenolol experiments: O2At: pool welloxygenated, no ischemia, atenolol present; N2At: pool experimental ischemia, atenolol present; Nebivolol experiments: Ob: pool well-oxygenated, nebivolol present; Nb: pool experimental ischemia, nebivolol present. It can be seen that, without the influence of betablockers, there is no significant regulation of PDK expression during myocardial ischemia. While there is no down-regulation of PDK gene expression by atenolol, there is a decrease in PDK gene expression in the presence of nebivolol both during normoxia and hypoxia. 167Nb, 167Ob, 236N2At and 236O2At are corresponding single-experiment controls.
 
PDK
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Figure/Graphic 3: PDK
In this figure, the results from microarray measurements of PDK experiments are illustrated. Pooled DNA data: Control experiments: Owo: pool control, well-oxygenated, no ischemia, no drug; Nwo: pool experimental ischemia, no drug; Atenolol experiments: O2At: pool welloxygenated, no ischemia, atenolol present; N2At: pool experimental ischemia, atenolol present; Nebivolol experiments: Ob: pool well-oxygenated, nebivolol present; Nb: pool experimental ischemia, nebivolol present. It can be seen that, without the influence of betablockers, there is no significant regulation of PDK expression during myocardial ischemia. While there is no down-regulation of PDK gene expression by atenolol, there is a decrease in PDK gene expression in the presence of nebivolol both during normoxia and hypoxia. 167Nb, 167Ob, 236N2At and 236O2At are corresponding single-experiment controls.
 
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