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Holzwart E, Gasser S, Roessl U, Buehner A, Ablasser K, Friehs I, Pieske B, Mächler H, Yates A, Tscheliessnig KH, Mangge H, Porta S, Gasser R Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium Journal of Clinical and Basic Cardiology 2010; 13 (1-4): 12-18 PDF Summary Overview
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Figure/Graphic 4: PCR - PDK The results from real-time PCR measurements of PDK experiments are illustrated (o2ko: well-oxygenated, no ischemia, no drug; n2ko: experimental ischemia, no drug; o2at: well-oxygenated, no ischemia, atenolol present; n2at: experimental ischemia, atenolol present; o2neb: well-oxygenated, nebivolol present; n2neb: experimental ischemia, nebivolol present). It can be seen that, without the influence of betablockers, there is no significant regulation of PDK expression during myocardial ischemia. There is just a trend towards a decrease in PDK gene expression. There is, however, a significant difference between the expression of PDK during myocardial ischemia in the presence of atenolol (3.62 ± 0. 18) and nebivolol (1.97 ± 0.06; ± SEM; P ≤ 0.05): PDK expression is decreased during normoxia (trend) and ischemia (significant) in the presence of nebivolol. |
Figure/Graphic 4: PCR - PDK
The results from real-time PCR measurements of PDK experiments are illustrated (o2ko: well-oxygenated, no ischemia, no drug; n2ko: experimental ischemia, no drug; o2at: well-oxygenated, no ischemia, atenolol present; n2at: experimental ischemia, atenolol present; o2neb: well-oxygenated, nebivolol present; n2neb: experimental ischemia, nebivolol present). It can be seen that, without the influence of betablockers, there is no significant regulation of PDK expression during myocardial ischemia. There is just a trend towards a decrease in PDK gene expression. There is, however, a significant difference between the expression of PDK during myocardial ischemia in the presence of atenolol (3.62 ± 0. 18) and nebivolol (1.97 ± 0.06; ± SEM; P ≤ 0.05): PDK expression is decreased during normoxia (trend) and ischemia (significant) in the presence of nebivolol. |