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Gasser R, Klein W  
Some observations and pathophysiological considerations concerning KATP-channels and coronary heart disease

Journal of Clinical and Basic Cardiology 1999; 2 (1): 15-18

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ANP-Freisetzung nach Ischämie
Figure 4: Liberation of atrionatriuretic peptide after a short ischaemic episode (PTCA of LAD) in patients with coronary heart disease. The inset shows the concentrations of ANP in the coronary sinus. The curve with open symbols shows the ANP-concentrations of patients from the antecubital vene. The fast rise of ANP leads to peripheral vasodilation, coronary dilatation and elimination of volume by strong diuresis. These mechanisms are cardioprotective by reducing pre- and afterload.

Keywords: ANPANPAtrial Natriuretic PeptideDiagrammischaemiaIschämie
Koronararterie - Dilatation
Figure 5A-C: Pig coronary artery precontracted with potassium-rich Tyrode solution: A: When 100 % oxygen is switched to 100 % nitrogen in the perfusate (simulation of ischaemia) and instantaneous dilation of the artery occurs. B: Tolbutamide, a specific blocker of KATP-channels leads to an inhibition of these mechanisms, hypoxic vasodilation is inhibited. C: Serial experiments on the inhibition of hypoxy coronary dilation using glibenclamide and other specific blockers of KATP-channels.

Keywords: Arteria coronariaArteria coronariaDilatationdilationGlibenclamidglibenclamideKaliumkanalpotassium channelTolbutamidtolbutamide
Autopräkonditionierung - Myokardinfarkt
Figure 6: Phenomenon of autopreconditioning. During the early phase of acute myocardial infarction, various parameters of ischaemia are subject to changes: ST-elevation, CK-MB, myoglobin as well as ANP rise and fall in an episodic manner. They reflect alternating phases of coronary artery occlusion and spontaneous reperfusion. PTCA, in contrast, only causes one peak in the ANPconcentration curve, as we see only one occlusion and one reperfusion (see figure 4).

Keywords: autopreconditioningAutopräkonditionierungDiagrammmyocardial infarctionMyokardinfarkt
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