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Gasser R, Klein W  
Some observations and pathophysiological considerations concerning KATP-channels and coronary heart disease

Journal of Clinical and Basic Cardiology 1999; 2 (1): 15-18

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Fig. 4: ANP-Freisetzung nach Ischämie Fig. 5A-C: Koronararterie - Dilatation Fig. 6: Autopräkonditionierung - Myokardinfarkt

Keywords: KATP-KanalNicorandilPräkonditionierungKATP-channelNicorandilpreconditioning

KATP-channels are involved in a multitude of cardioprotective mechanisms: The shortening of the cardiac action potential with subsequent decrease of Ca-entry and reduction of contractile force (reduced O2-consumption), ischaemic K-efflux and preconditioning. Myocardial hibernation, another cardioprotective mechanism, is also initially triggered by the opening of KATP-channels. Drugs, like K-channel-openers, hence, are beneficial in coronary heart disease. They support the physiological mechanisms of anti-ischaemic protection. This article describes the various phenomena of anti-ischaemic protection in great detail. J Clin Basic Cardiol 1999; 2: 15-8.
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