Abbildung 5: KHK - Sekundärprävention
Indeed, looking more closely at the very important formation of bradykinin and pharmacological mode of action of ACEIs, we can conclude that bradykinin is one of the most important consequence of ACE inhibition. Bradykinin stimulates the release of NO from the endothelium, which not only dilates the vessel but also reduces platelet aggregation, the activity of white cells, and smooth muscle cell hypertrophy, all of which result from the activities of angiotensin II. Damage to the endothelium by smoking, hypercholesterolemia, diabetes, hypertension, or superoxides inhibits NO release, allowing angiotensin II to exert the harmful effects, as represented on the left side of the figure. SMC = glatte Muskelzellen FGF = Fibroblasten Growth Factor PDGF = Platelet Derived Growth Factor