Abbildung 11: Telmisartan - Losartan - Studienverlauf
In a meta-analysis of two flexible-dose studies, telmisartan-induced reductions in DBP during the last 6 h of the dosing interval were greater than those with losartan.1 Reductions with telmisartan were greater than with losartan for the majority of the observed hourly mean values over the entire 24-h dosing interval.1 These data are from two, 8-week studies in 720 patients with mild-to-moderate hypertension.1 Patients were started at the lower dose, with up-titration to the higher dose allowed if seated trough cuff DBP was ≥90 mmHg at Week 4. The 24-h profiles of ambulatory SBP hourly mean reductions were similar to those for DBP. 1. Smith DH, et al. Comparison of telmisartan versus losartan: meta-analysis of titration-to-response studies. Blood Press Monit 2003; 8: 111–117.