Abbildung 12: Telmisartan - Losartan - Systolischer Minimaldruck
In flexibly dosed studies using trough cuff blood pressure as the primary outcome, telmisartan was found to be superior to losartan. Lee et al. compared telmisartan 40–80 mg with losartan 50–100 mg in an 8-week study of 180 Taiwanese patients with mild-to-moderate hypertension.1 Changes in SBP were statistically superior with telmisartan compared with losartan. Changes in DBP (amounting to 11.1 mmHg with telmisartan and 8.7 mmHg with losartan) did not reach statistical significance. Zhu et al. compared telmisartan 40–80 mg with losartan 50–100 mg in an 8-week study of 330 Chinese patients with mild-to-moderate hypertension.2 Changes in SBP were statistically superior with telmisartan compared with losartan. Changes in DBP (amounting to 10.9 mmHg with telmisartan and 9.3 mmHg with losartan) were also statistically significant (p=0.03). 1. Lee YT, et al. A double-blind comparison of the efficacy and tolerability of telmisartan 40-80 mg vs. losartan 50-100 mg in Taiwanese hypertensive patients. Int J Clin Pract Suppl 2004; 58: 40–45. 2. Zhu JR, et al. Efficacy and safety of telmisartan vs. losartan in control of mild-to-moderate hypertension: a multicentre, randomised, double-blind study. Int J Clin Pract Suppl 2004; 58: 46–49.