Abbildung 22: Telmisartan - Amlodipin
Telmisartan produced reductions in DBP in the last 4 h of the dosing interval that were superior to amlodipine in this 12-week, double-blind, titration-to-response, ABPM study.1 Patients (n=232) had mild-to-moderate hypertension. They were randomized to placebo (n=81) or active dose, which comprised telmisartan 40 mg or amlodipine 5 mg titrated as required up to a maximum of telmisartan 120 mg or to amlodipine 10 mg. Compared with amlodipine, telmisartan resulted in a 26% reduction in SBP and an almost 40% reduction in DBP during the last 4 h of the dosing interval. 1. Lacourcière Y, et al. A comparison of the efficacies and duration of action of the angiotensin II receptor blockers telmisartan and amlodipine. Blood Press Monit 1998; 3: 295–302.