Abbildung 35: Telmisartan - HCTZ
This study, A comparison of Telmisartan plus HCTZ with amlodipine plus HCTZ in Older patients with predominantly Systolic hypertension (ATHOS) compared telmisartan 40–80 mg + HCTZ 12.5 mg with amlodipine 5–10 mg + HCTZ 12.5 mg.1 On entry, the patients had seated SBP >140 mmHg, seated DBP ≤95 mmHg and 24-h mean ambulatory SBP 125 mmHg. They were elderly (≥60 years old). The primary endpoint, the change from baseline in SBP in the last 6 h of the dosing interval, was not significantly different between the two groups. However, SBP was significantly reduced with telmisartan + HCTZ compared with amlodipine + HCTZ over the 24 h, morning and daytime periods. SBP control rates (24-h mean SBP <140 mmHg) were also significantly greater (p=0.0175) with telmisartan + HCTZ (65.9%) than with amlodipine + HCTZ (58.3%). 1. Data on file. Boehringer Ingelheim, GmbH.