Abbildung 38: Telmisartan - HCTZ
Because African-American (black) patients may have low plasma renin activity, they can show an especially improved response to ARBs when HCTZ is added. Reported here are the results from 222 African-American patients who took part in an 8-week, 4 x 5 factorial, multicentre, double-blind, placebo-controlled, dose-finding study conducted in patients (total n=818) with mild-to-moderate hypertension.1 Patients were randomized to telmisartan 20 mg, 40 mg, 80 mg or 160 mg alone or in combination with HCTZ 6.25 mg, 12.5 mg, or 25 mg, giving a total of 20 treatment groups. Key arms are shown in this slide. Telmisartan/HCTZ reduced blood pressure compared with HCTZ monotherapy. The magnitude of the response was similar to that observed in the full patient population. 1. McGill JB, Reilly PA. Combination treatment with telmisartan and hydrochlorothiazide in black patients with mild to moderate hypertension. Clin Cardiol 2001; 24: 66–72.