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Fitzgerald JS, Poehlmann TG, Suman P, Gupta SK, Schleussner E, Markert  UR
Signal Transducer and Activator of Transcription 3 (STAT3) and Trophoblast Invasion
Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2007; 4 (6): 322-330

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Aktuelles Bild - Abb. 1: Implantation window Abb. 2: Jak-STAT signal transducing pathway
Abbildung 1: Implantation window
Plate 1 depicts gradual apposition of blastocyst to endometrium during the onset of the implantation window, delineated here by putative biomarkers for endometrial receptivity: integrins (red), pinopodes (violet) and LIF (orange). Trophectodermal integrins (green) on the apical membrane surface of the blastocyst are necessary for adhesion (Plate 2). Adhesion induces reaction in trophoblast cells to differentiate into inner cytotrophoblast (dark pink) and outer syncytiotrophoblast (light pink) layers. Syncytiotrophoblasts are large, polymorph, possess several nuclei and initially invade the decidua (Plate 3). Trophoblasts now produce pregnancy-conserving β-hCG (not depicted in this scheme), which stimulates the corpus luteum to produce progesterone. In plate 4, implantation is complete. The implantation window is now closed.
 
Implantation window
Vorheriges BildNächstes Bild   


Abbildung 1: Implantation window
Plate 1 depicts gradual apposition of blastocyst to endometrium during the onset of the implantation window, delineated here by putative biomarkers for endometrial receptivity: integrins (red), pinopodes (violet) and LIF (orange). Trophectodermal integrins (green) on the apical membrane surface of the blastocyst are necessary for adhesion (Plate 2). Adhesion induces reaction in trophoblast cells to differentiate into inner cytotrophoblast (dark pink) and outer syncytiotrophoblast (light pink) layers. Syncytiotrophoblasts are large, polymorph, possess several nuclei and initially invade the decidua (Plate 3). Trophoblasts now produce pregnancy-conserving β-hCG (not depicted in this scheme), which stimulates the corpus luteum to produce progesterone. In plate 4, implantation is complete. The implantation window is now closed.
 
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