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1. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Ultrastructural morphometry (4500x). A: longitu dinal section of control rat heart subjected to 20 min. ischaemia and reperfusion; interstitial and interfibrils oedema, severe mitochondria damage and endothelial lesions are detected. B: effect of DPCPX 100 nM: a significant reduction of ultrastructural damage is reported. M: mitochondria, ISE: interstitial oedema, IFE: nterfibrils oedema, E: endothelium. Keywords: Adenosin,
adenosine,
Histologisches Präparat,
histology,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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2. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Histological samples (200x, fluorescent light) showing the FITC-albumin diffusion. A: control heart submitted to 20 min global ischaemia, B) effect of 100 nm DPCPX: a significant reduction of perivascular (PV, left) and perimyocytic (PM, right) fluorescence is detected. Keywords: Adenosin,
adenosine,
Histologisches Präparat,
histology,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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3. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Effects of DPCPX on microvascular permeability. Quantitative assessment of FITC-albumin extravasation expressed as IOI (integrated optical intensity; see Material and methods) units; data are expressed as mean and SD. * = p < 0.02 vs. KH. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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4. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Purine release (nmol x min-1 x gr.dw-1). Time course of nucleosides (adenosine, inosine) and metabolites (hypoxanthine and uric acid) in all groups. Data are expressed as mean and SD. * = p = 0.05; ** = p < 0.001. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation,
Purin,
purine
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5. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Time course of coronary flow (CF: ml/min) in nonischaemic hearts (top) and after 10 (middle) and 20 min. (bottom) ischaemia. Data are expressed as mean and SD; * = p < 0.01 vs. KH perfusion. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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6. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Heart weight changes: wet weight/dry weight (ww/dw) in all experimental groups. Data are expressed as mean and SD: * = p < 0.01 vs. KH perfused hearts. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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7. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Experimental protocol Keywords: Adenosin,
adenosine,
Design,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation,
Schema
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