Abbildung 17: Perindopril - Widerstandsarterien
Perindopril normalises structure of coronary resistance arteries in patients with hypertensive heart disease. In the study where hypertensive patients with LVH and microvascular angina, were treated with perindopril 4 mg to 8 mg for 1 year, after the treatment period, perindopril had significantly decreased coronary resistance. Perindopril induced the regression of periarteriolar fibrosis of resistance vessels and of the interstitial collagen. This was accompanied by marked improvement in coronary reserve. These findings indicate the beneficial reparative effects of ACE inhibition with perindopril on coronary microcirculation in hypertensive heart disease, beyond BP control.