Abbildung 20: Perindopril - Antiatheriosklerotischer Effekt
In a study on diabetic apoE-deficient mice, perindopril shows its ability to oppose the development of atherosclerosis by inhibiting ACE tissue growth factor and vascular cell adhesion molecule-1 overexpression in the aorta. This experimental study clearly proves perindopril’s efficacy on atherosclerosis in at-risk diabetic animal models. Perindopril plays a pivotal role in the opposition of development and acceleration of atherosclerosis in diabetes. Candido R, Jandeleit-Dahm KA, Cao Z, et al. Circulation. 2002; 106: 246-53.