Abbildung 19: Perindopril - Fibrinolyse
It has been confirmed that in hypertensive and cardiovascular disease the reduced levels of tissue-type plasminogen activator (t-PA), are contributing to thrombus formation. This plays a role in the pathogenesis of acute myocardial infarction and stroke. In a recent trial which compared the effects of perindopril and losartan on fibrinolytic balance in coronary artery circulation of the patients with atypical chest pain and hypertension, perindopril increased t-PA enhanced by bradykinin significantly more than losartan.