Abbildung 22: Perindopril - Verträglichkeit
First dose hypotension in heart failure patients with the initiation of an ACEI may be symptomatic or asymptomatic, which may lead to renal, cardiac, or cerebral hypoperfusion. In the double-blind, randomized, placebo-controlled, parallel-group prospective study of elderly patients with stable chronic heart failure, perindopril demonstrated an excellent hemodynamic tolerance minimizing the risk of hypotension. Perindopril 2 mg produces no more decrease in blood pressure then placebo. On the contrary, enalapril and captopril induce significant and long-lasting reduction in mean arterial pressure. Perindopril once daily provides an excellent hemodynamic profile even in fragile patients. So, for all these reasons perindopril was chosen to conduct EUROPA study. Mc Fadyen J, Lees K R, Reid J L. Br Heart J. 1991; 66: 206-11.