Abbildung 17: Telmisartan - Ramipril
Telmisartan 80 mg reduces blood pressure over the full 24-h dosing interval compared with ramipril 10 mg. Data shown are from a fixed-dose, 14-week study: PRISMA II.1 Patients were started on telmisartan 40 mg or ramipril 2.5 mg, force titrated to telmisartan 80 mg or ramipril 5 mg after 2 weeks. At Week 8, ramipril was further up titrated to 10 mg. Blood pressure was measured using ABPM. Telmisartan was significantly superior to ramipril (p<0.0001) over the 24-h mean and other time periods: morning (06:00–11:59), daytime (06:00–21:59), and night-time (22:00–05:59). 1. Lacourcière Y, et al. A prospective, randomized investigation of the safety and efficacy of telmisartan vs ramipril in mild-to-moderate hypertensives using ambulatory blood pressure monitoring. Hypertension 2004; 44: 576.