Figure/Graphic 4A-D: Doxorubicin - Angiotensin-II-Modulation
Time courses of left-ventricular pressure (LVP) in isolated rat heart before (left figures) and during vagus stimulation (10 Hz, 10 V, 10 s stimulation period, right figures), recorded during Tyrode perfusion, Tyrode + doxorubicin (DXR) perfusion and Tyrode + DXR + angiotensin II (AII) perfusion. 20 micromol/L DXR and 1 micormol/L AII were applied in this experiment. AII was added 26 minutes after DXR administation. A Tyrode perfusion, B after 24 min perfusion with Tyrode + DXR, C after 5 min perfusion with Tyrode + DXR + AII (31 min after DXR application) and D 3 minutes later than C (after 8 min perfusion with Tyrode + DXR + AII, 34 min after DXR application = end of the experiment). Horizontal bars (right figures) mark the time period of vagus stimulation.