Figure/Graphic 5A-D: Doxorubicin - Angiotensin-II-Modulation
Dose-dependence of the changes in vagus stimulation (right N. vagus, 10 Hz, 10 V) effects on heart rate (HR, A), SαT time (B) and time constant of contraction τC (C) during perfusion of isolated rat hearts with doxorubicin (DXR)-containing Tyrode. 10 micromol/L DXR: solid line and open squares, 20 micromol/L DXR: dash-dotted line and filled circles, 40 micromol/L DXR: dashed line and open rhombs. Vagus stimulation effects before DXR addition to Tyrode were set to 100 %. Vagus stimulation effects were recorded 10 min after start of DXR perfusion and shortly before the end of each experiment (duration of experiments was the shorter the higher the DXR doses: hearts beated about 60 min after addition of 10 micro mol/L DXR, 40 min after addition of 20 micro mol/L DXR and 25 min after addition of 40 micro mol/L DXR). Means and SD of 5 experiments. Asterisks, significant changes compared with control values before DXR perfusion (P < 0.05).