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Schweppe KW, Rabe T, Langhardt M, Woziwodzki J, Petraglia F, Kiesel L Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119 Volltext (PDF) Summary Übersicht
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Abbildung 9: Vicious circle in the endometrial focus Vicious circle in the endometrial focus maintains the proliferation and inflammatory reaction: (1) local estrogen is produced by aromatase activation; (2) estrogens stimulate prostaglandin synthesis via the activation of the COX-2 enzyme; (3) Prostaglandin E-2 again stimulates aromatase. Whether the aromatase is activated in the endometrial lesion itself or in the surrounding zissue (fat, peritoneum) is controversial. |
Abbildung 9: Vicious circle in the endometrial focus
Vicious circle in the endometrial focus maintains the proliferation and inflammatory reaction: (1) local estrogen is produced by aromatase activation; (2) estrogens stimulate prostaglandin synthesis via the activation of the COX-2 enzyme; (3) Prostaglandin E-2 again stimulates aromatase. Whether the aromatase is activated in the endometrial lesion itself or in the surrounding zissue (fat, peritoneum) is controversial. |