1.
Wieacker P
Genetic Aspects of Premature Ovarian Failure
Hypergonadotropic hypogonadism
Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2009; 6 (1): 17-18
Possible mechanisms of hypergonadotropic hypogonadism in females. (A) In normal ovaries maturation of follicles is beginning at the time of puberty. (B) In case of maturation arrest only primordial or primary follicles are
present. Basic estradiol production of granulosa cells makes breast development possible, but there is a primary amenorrhea. FSHβ-, FSHR- or LHR-mutations can cause such a condition. (C) In secondary POF, maturation of follicles at puberty makes menarche and breast development possible, but early depletion of follicles causes secondary
amenorrhea. Such a condition can be caused by Turner mosaicism. (D) In primary POF, depletion of follicles before the puberty causes primary amenorrhea. Breast development is not possible. (E) In gonadal dysgenesis degeneration of
the follicles occurs during fetal life. In the rule, primary POF and gonadal dysgenesis cannot be delineated clinically.
Keywords:
POF
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