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1. Nagel B;
Maier R;
Gasser S;
Mair J
Pathophysiologie und Diagnostik komplexer angeborener Herzfehler
System- und Lungenkreislauf
Journal für Kardiologie - Austrian Journal of Cardiology 2015; 22 (3-4): 63-69
(a): Schema des normalen,
in Serie geschalteten System- und Lungenkreislauf;
(b): System- und Lungenkreislauf
sind bei Patienten mit singulärem Ventrikel
(SV) parallel geschaltet.
Rp = Lungenwiderstand; Rs = Systemwiderstand. Keywords: Lungenkreislauf,
Schema,
Systemkreislauf
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2. Nagel B;
Maier R;
Gasser S;
Mair J
Pathophysiologie und Diagnostik komplexer angeborener Herzfehler
Transthorakale Echokardiographie
Journal für Kardiologie - Austrian Journal of Cardiology 2015; 22 (3-4): 63-69
Transthorakale Echokardiographie, die die linksgelegene Trikuspidaklappe
(gehört immer zum RV) zeigt, deren Ansatz weiter apikalwärts ist als die
rechtsgelegene Mitralklappe (gehört immer zum LV). Keywords: Echokardiographie,
LV,
RV
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3. Nagel B;
Maier R;
Gasser S;
Mair J
Pathophysiologie und Diagnostik komplexer angeborener Herzfehler
Transthorakale Echokardiographie
Journal für Kardiologie - Austrian Journal of Cardiology 2015; 22 (3-4): 63-69
Transthorakale Echokardiographie mit Darstellung des systemvenösen Atriums (SV) mit Fluss in den LV; (b): Pulmonalvenöses Atrium (PV) mit Fluss in den RV. Keywords: Echokardiographie,
LV,
PV,
RV,
SV
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4. Nagel B;
Maier R;
Gasser S;
Mair J
Pathophysiologie und Diagnostik komplexer angeborener Herzfehler
Kardiales MRT
Journal für Kardiologie - Austrian Journal of Cardiology 2015; 22 (3-4): 63-69
(a): Kardiales MRT mit dilatiertem rechten
Vorhof und Ventrikel (RA, RV) als Folge einer langjährigen
Pulmonalinsuffizienz; (b): MRT 1 Jahr postoperativ
nach Implantation einer Homograftklappe als Pulmonalklappenersatz. Keywords: Homograftklappe,
Kardiales MRT,
Pulmonalinsuffizienz
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5. Nagel B;
Maier R;
Gasser S;
Mair J
Pathophysiologie und Diagnostik komplexer angeborener Herzfehler
Fallot'sche Tetralogie
Journal für Kardiologie - Austrian Journal of Cardiology 2015; 22 (3-4): 63-69
(a): Fallot’sche Tetralogie mit Deviation des „outlet“ Septums (Stern) in den rechtsventrikulären Ausflusstrakt mit der Folge einer Subpulmonalstenose; (b): Kurze Achse einer transthorakalen Echokardiographie mit verdickter und dysplastischer Pulmonalklappe. PA = Pulmonalarterie; VSD = Ventrikelseptumdefekt Keywords: Echokardiographie,
Fallot’sche Tetralogie,
Schema
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6. Eltbogen R;
Litschgi M;
Gasser UE;
Flüeli A;
Nebel S;
Zahner C
Vitex-agnus-castus-Extrakt (Ze 440) zur Symptombehandlung bei Frauen mit menstruellen Zyklusstörungen
Zyklusstörungen-Behandlung
Journal für Gynäkologische Endokrinologie 2015; 9 (2) (Ausgabe für Österreich): 10-15
Journal für Gynäkologische Endokrinologie 2015; 9 (2) (Ausgabe für Schweiz): 9-14
Bewertung der Behandlungsergebnisse durch die Ärzte und Behandlungszufriedenheit der Patientinnen: Prozentsatz der Ärzte und Patientinnen, die sehr zufrieden, zufrieden, unzufrieden oder sehr unzufrieden mit den klinischen Ergebnissen waren. Keywords: Behandlungszufriedenheit,
Beobachtungsstudie,
Diagramm,
Gynäkologie,
Vitex agnus-castus (VAC)
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7. Eltbogen R;
Litschgi M;
Gasser UE;
Flüeli A;
Nebel S;
Zahner C
Vitex-agnus-castus-Extrakt (Ze 440) zur Symptombehandlung bei Frauen mit menstruellen Zyklusstörungen
Zyklusstörungen-Behandlung
Journal für Gynäkologische Endokrinologie 2015; 9 (2) (Ausgabe für Österreich): 10-15
Journal für Gynäkologische Endokrinologie 2015; 9 (2) (Ausgabe für Schweiz): 9-14
Besserung von (a) menstruellen Zyklusstörungen (MCIs) allgemein und von spezifischen Beschwerdebildern wie Polymenorrhö, Oligomenorrhö und Amenorrhö und (b) Symptomen im Zusammenhang mit der Menstruationsblutung bei der Kontrolluntersuchung:
Vollständige Remission, verbesserte, unveränderte oder verschlechterte Symptome in Prozent. Keywords: Amenorrhö,
Beobachtungsstudie,
Diagramm,
Gynäkologie,
menstruelle Zyklusstörung,
Oligomenorrhö,
Polymenorrhö,
Vitex agnus-castus (VAC)
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10. Gasser RW;
Pichler R;
Heidegger I;
Kroiss A;
Uprimny C;
Steiner H
Klinische Vignette: Katecholamin-sezernierendes Paragangliom der Harnblase
Paragangliom-Harnblase
Journal für Klinische Endokrinologie und Stoffwechsel - Austrian Journal of Clinical Endocrinology and Metabolism 2014; 7 (3): 102-103
Links: Computertomographie des Beckens mit Tumormasse an der vorderen Blasenwand (5 × 5 × 6 cm). Rechts: Szintigraphie mit 123I-MIBG mit isolierter und vermehrter Tracer-Aufnahme rechts paramedian im vorderen Bereich der Harnblase. Mod. nach [1]. Keywords: Computertomographie,
Harnblase,
Szintigraphie,
Tumor
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11. Gasser S;
Zunko S;
Kraigher-Krainer E;
Gasser R
White-Coat Hypertension and Socio-Interactive Dynamics: A Case Report
Blood Pressure
Journal of Clinical and Basic Cardiology 2011; 14 (1-4): 23-24
(a) Systolic blood pressure in mmHg; (b) Diastolic blood
pressure in mmHg; Sample: BP assessment by different persons:
measurement by patient (1), daughter (2), mother (3), pharmacist
(4), GP (5), and professor of internal medicine (6). One can see the
reproducible socio-emotional dynamics of both systolic and diastolic
blood pressures in this patient. Number of measurements for each
sample: 5. Keywords: blood pressure
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12. Gasser R;
Pätzold S;
Holzwart E;
Ablasser K;
Kraigher-Krainer E;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Porta S;
Gasser S
Immunological Implications in Experimental Myocardial Ischaemia: MPO (Myeloperoxidase) Expression Is Differentially Regulated by Beta-Blockers, While CD80 Expression Remains Unaffected
CD80 Experiments
Journal of Clinical and Basic Cardiology 2011; 14 (1-4): 16-22
It shows the results from real-time PCR measurements of
all CD80 experiments (o2ko: well-oxygenated, no ischaemia, no
drug; n2ko: experimental ischaemia, no drug; o2at: well-oxygenated,
no ischaemia, atenolol present; n2at: experimental ischaemia,
atenolol present; o2neb: well-oxygenated, nebivolol present; n2neb:
experimental ischaemia, nebivolol present). It can be seen that during
experimental ischaemia, there is an up-regulation of CD80 expression.
There is also a regulation with and without the influence of
beta-blockers during myocardial ischaemia. Keywords: CD80,
flowchart
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13. Gasser R;
Pätzold S;
Holzwart E;
Ablasser K;
Kraigher-Krainer E;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Porta S;
Gasser S
Immunological Implications in Experimental Myocardial Ischaemia: MPO (Myeloperoxidase) Expression Is Differentially Regulated by Beta-Blockers, While CD80 Expression Remains Unaffected
Interleukin Pathway
Journal of Clinical and Basic Cardiology 2011; 14 (1-4): 16-22
Interleukin pathway up-regulated by nebivolol, not by
atenolol, during experimental ischaemia. Keywords: flowchart,
interleukin
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14. Gasser R;
Pätzold S;
Holzwart E;
Ablasser K;
Kraigher-Krainer E;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Porta S;
Gasser S
Immunological Implications in Experimental Myocardial Ischaemia: MPO (Myeloperoxidase) Expression Is Differentially Regulated by Beta-Blockers, While CD80 Expression Remains Unaffected
MPO Experiments
Journal of Clinical and Basic Cardiology 2011; 14 (1-4): 16-22
It shows the results from real-time PCR measurements of
all MPO experiments (o2ko: well-oxygenated, no ischaemia, no
drug; n2ko: experimental ischaemia, no drug; o2at: well-oxygenated,
no ischaemia, atenolol present; n2at: experimental ischaemia,
atenolol present; o2neb: well-oxygenated, nebivolol present; n2neb:
experimental ischaemia, nebivolol present). Using PCR for validation,
we find that during experimental ischaemia, there is an up-regulation
of MPO expression. There is a differential regulation between
different beta-blockers during myocardial ischaemia, which warrants
further investigation. Keywords: flowchart,
MPO
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15. Holzwart E;
Gasser S;
Roessl U;
Buehner A;
Ablasser K;
Friehs I;
Pieske B;
Mächler H;
Yates A;
Tscheliessnig KH;
Mangge H;
Porta S;
Gasser R
Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium
PCR - PDK
Journal of Clinical and Basic Cardiology 2010; 13 (1-4): 12-18
The results from real-time
PCR measurements of PDK experiments
are illustrated (o2ko: well-oxygenated,
no ischemia, no drug; n2ko:
experimental ischemia, no drug; o2at:
well-oxygenated, no ischemia, atenolol
present; n2at: experimental ischemia,
atenolol present; o2neb: well-oxygenated,
nebivolol present; n2neb: experimental
ischemia, nebivolol present). It
can be seen that, without the influence
of betablockers, there is no significant
regulation of PDK expression during
myocardial ischemia. There is just a
trend towards a decrease in PDK gene
expression. There is, however, a significant
difference between the expression
of PDK during myocardial ischemia in
the presence of atenolol (3.62 ± 0. 18)
and nebivolol (1.97 ± 0.06; ± SEM;
P ≤ 0.05): PDK expression is decreased
during normoxia (trend) and ischemia
(significant) in the presence of nebivolol. Keywords: flowchart,
PCR,
PDK
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16. Holzwart E;
Gasser S;
Roessl U;
Buehner A;
Ablasser K;
Friehs I;
Pieske B;
Mächler H;
Yates A;
Tscheliessnig KH;
Mangge H;
Porta S;
Gasser R
Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium
PDK
Journal of Clinical and Basic Cardiology 2010; 13 (1-4): 12-18
In this figure, the results from
microarray measurements of PDK experiments
are illustrated. Pooled DNA data:
Control experiments: Owo: pool control,
well-oxygenated, no ischemia, no drug;
Nwo: pool experimental ischemia, no drug;
Atenolol experiments: O2At: pool welloxygenated,
no ischemia, atenolol present;
N2At: pool experimental ischemia, atenolol
present; Nebivolol experiments: Ob: pool
well-oxygenated, nebivolol present; Nb:
pool experimental ischemia, nebivolol
present. It can be seen that, without the influence
of betablockers, there is no significant
regulation of PDK expression during
myocardial ischemia. While there is no
down-regulation of PDK gene expression
by atenolol, there is a decrease in PDK gene
expression in the presence of nebivolol
both during normoxia and hypoxia. 167Nb,
167Ob, 236N2At and 236O2At are corresponding
single-experiment controls. Keywords: flowchart,
PDK
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17. Holzwart E;
Gasser S;
Roessl U;
Buehner A;
Ablasser K;
Friehs I;
Pieske B;
Mächler H;
Yates A;
Tscheliessnig KH;
Mangge H;
Porta S;
Gasser R
Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium
Gene expression
Journal of Clinical and Basic Cardiology 2010; 13 (1-4): 12-18
Gene expression of biological processes associated with
glucose metabolism during normoxia and hypoxia is down-regulated
in human atrial tissue. Up-regulation of gene-expression associated
with glucose metabolism during hypoxia. Keywords: flowchart,
gene expression
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18. Holzwart E;
Gasser S;
Roessl U;
Buehner A;
Ablasser K;
Friehs I;
Pieske B;
Mächler H;
Yates A;
Tscheliessnig KH;
Mangge H;
Porta S;
Gasser R
Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium
Gene expression
Journal of Clinical and Basic Cardiology 2010; 13 (1-4): 12-18
Example of differential regulation of gene expression by atenolol and nebivolol in well-oxygenized preparations: one can see that
numerous biochemical processes are affected by nebivolol but not by atenolol. For example, many processes involved in contraction, lipid
metabolism, and proliferation are down-regulated by nebivolol only (not by atenolol). Reducing lipid metabolism in exchange for an increased
carbohydrate metabolism may render the heart less vulnerable to O2 deficit or ischemia. Keywords: flowchart,
gene expression
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19. Gasser R;
Roessl U;
Holzwart E;
Ablasser K;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Gasser S
Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters
Myocardial Metabolism
Journal of Clinical and Basic Cardiology 2009; 12 (1-4): 11-17
Plasticity of myocardial metabolism: during exercise, hypoxia/
ischemia etc myocardial cells prefer glucose as a substrate. Both
fasting and diabetes shift the metabolic substrates to the fatty acid
site. Mod. from [29, 33]. Keywords: chart,
Diagramm
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20. Gasser R;
Roessl U;
Holzwart E;
Ablasser K;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Gasser S
Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters
Cardiac metabolism
Journal of Clinical and Basic Cardiology 2009; 12 (1-4): 11-17
Shifting cardiac metabolism to its fetal phenotype: as an
anti-anginal target (mod. from [32]) of dichloracetate augments cellular
glucose metabolism. Etoximir and perhexiline inhibit cellular
fatty acid metabolism and both ranolazine as well as trimetazidine
slow down beta oxidation. Beta-adrenergic blockade enhances
GLUT1 and GLUT4 expressions. Keywords: Schema,
scheme
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21. Gasser R;
Roessl U;
Holzwart E;
Ablasser K;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Gasser S
Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters
Glucose metabolism
Journal of Clinical and Basic Cardiology 2009; 12 (1-4): 11-17
(a) Gene expression of biological processes associated
with glucose metabolism during normoxia and hypoxia. Up-regulation of glucose metabolism. (b) Down-regulation of gene expression of biological processes associated with fatty acid and amino acid
metabolism – (a) and (b) indicate a conversion to the fetal type of metabolism. Based on data from [4–9, 32–35]. Keywords: chart,
Diagramm
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22. Gasser R;
Roessl U;
Holzwart E;
Ablasser K;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Gasser S
Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters
Myocardial Metabolism
Journal of Clinical and Basic Cardiology 2009; 12 (1-4): 11-17
Substrates of myocardial metabolism. Mod. from [29, 32]. The fetal myocardial phenotype uses predominantly glucose for its
metabolism, whereas the adult individual mainly metabolises fatty
acids. During special conditions, like hypoxia, the adult phenotype of
myocardial metabolism converts to the fetal phenotype, again preferably
using glucose for its metabolism (Fig. 4). It has been shown
that a preferentially glucose-oriented cardiac metabolism is beneficial
in myocardial ischemia. However, knockout experiments have
shown that successful transfer to the fetal metabolism is possible
only under adequate/increased GLUT1 expression [33–35]. Keywords: chart,
Diagramm
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23. Gasser R;
Roessl U;
Holzwart E;
Ablasser K;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Gasser S
Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters
Real-time PCR
Journal of Clinical and Basic Cardiology 2009; 12 (1-4): 11-17
Results from real-time PCR measurements of all GLUT4
experiments (o2ko = well-oxygenated, no ischemia, no drug; n2ko =
experimental ischemia, no drug; o2at = well-oxygenated, no ischemia,
atenolol present; n2at = experimental ischemia, atenolol present;
o2neb = well-oxygenated, nebivolol present; n2neb = experimental
ischemia, nebivolol present). It can be seen that during experimental
ischemia, there is an up-regulation of GLUT4 (SLC2A4) expression,
however not statistically significant. Keywords: chart,
Diagramm
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24. Gasser R;
Roessl U;
Holzwart E;
Ablasser K;
Friehs I;
Lewinski D;
Pieske B;
Mächler H;
Trantiner-Yates A;
Tscheliessnig KH;
Mangge H;
Gasser S
Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters
Real-time PCR
Journal of Clinical and Basic Cardiology 2009; 12 (1-4): 11-17
Results from real-time PCR measurements of 72 experiments (n = 12 in each group; o2ko = well-oxygenated, no ischemia,
no drug; n2ko = experimental ischemia, no drug; o2at = well-oxygenated,
no ischemia, atenolol present; n2at = experimental ischemia,
atenolol present; o2neb = well-oxygenated, nebivolol present;
n2neb = experimental ischemia, nebivolol present). It can be seen
that during experimental ischemia, there is an up-regulation of
GLUT1 expression, however, not statistically significant. This confirms
earlier data by our group. While there is no significant regulation
with and without the influence of beta blockers during myocardial
ischemia either, there is, however, a significant difference between
the expression of GLUT1 in well-oxygenized preparations with
(0.87 ± 0.02) and without nebivolol (0.62 ± 0.02; ± SEM; p ≤ 0.05).
Similarly, atenolol led to an increase of GLUT1 expression in welloxygenated
preparations compared to controls: 1.18 ± 0.08 and
0.62 ± 0.02, respectively (+ SEM; p < 0.05) Keywords: chart,
Diagramm
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25. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Nebivolol - Biological Pathway
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
Concerning nebivolol-regulated biological pathways, we could see that, during normoxia, up-regulation of pathways is hardly pronounced by nebivolol over atenolol. This becomes evident also in Figure 9a, only 3
pathways are affected here. Noteworthy here, too, the interleukin signalling pathway. Keywords: Atenolol,
flowchart,
Nebivolol
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26. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Pathway - Up-Regulation
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
Generally, we could see that, during experimental ischemia, upregulation of pathways is minimal by nebivolol over atenolol. This becomes
evident in Figure 9a, only 3 pathways are affected. However, the interleukin signalling pathway may be of interest in connection with inflammation, scarring
and remodelling. Keywords: Atenolol,
flowchart,
ischaemia,
Nebivolol
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27. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Biological Pathways
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
In well-oxygenized preparations, we can see that numerous biological pathways, mainly those involved in signalling, angiogenesis, cellular immunity, and EGF are affected by nebivolol but not by atenolol. Keywords: Atenolol,
biological pathway,
flowchart,
Nebivolol
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28. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Gene expression
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
It is interesting that nebivolol but not atenolol leads to a downregulation of gene expression in glutamine-glutamate conversion and pyruvate
metabolism, the latter of particular interest in ischemia. Keywords: Atenolol,
flowchart,
gene expression,
Nebivolol
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29. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Well-oxygenized preparations
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
In well-oxygenized preparations, we can see that numerous biochemical processes are up-regulated by nebivolol (not by atenolol). Interesting are reverse transcription, stress response, and protein phosphorylation. Keywords: biochemical process,
flowchart
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30. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Biochemical process
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
In well-oxygenized preparations, we can see that numerous biochemical processes, mainly those involved in signalling and cellular immunity, are affected by nebivolol but not by atenolol. In the lower part, we can see that many processes involved in contraction, lipid metabolism, and proliferation are down-regulated by nebivolol only (not by atenolol). This kind of
processes, if slowed down, may render the heart less vulnerable to O2 deficit or ischemia. Keywords: biochemical process,
flowchart
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31. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Nebivolol - Atenolol
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
Similarly, as in Figure 4, biological processes involved in cell-mediated immunity and reverse transcription are significantly up-regulated by nebivolol and not by atenolol. One may deduce that both cellular immunity
as well as reverse transcription are regulated by nebivolol at various sites. Keywords: Atenolol,
flowchart,
Nebivolol
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32. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Nebivolol - Atenolol
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
This figure shows biological processes more than twofold downregulated in the presence of nebivolol but unaffected by atenolol during simulated ischemia (100 % O2 replaced by 100 % N2 perfusion). One can
see that, in particular on the level of reverse transcription and T-cell-mediated immunity as well as in the process of angiogenesis, a noteworthy regulation
is brought about by nebivolol. Keywords: Atenolol,
flowchart,
Nebivolol
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33. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Hypoxia
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
Panels A und B show all genes regulated significantly during experimental myocardial ischemia (hypoxia) in the presence and absence of either atenolol or nebivolol. Panel A (red) summarizes all
genes down-regulated by nebivolol compared to those up-regulated by atenolol during hypoxia. N2 control indicates gene expression in ischemic preparations without betablockers. N2 nebivolol indicates gene expression in the presence of nebivolol in ischemic preparations.
The red and green lines indicate the direction of gene regulation. On the left side of panel A, N2 atenolol represents genes upregulated under atenolol during hypoxia. Panel B, accordingly, shows all genes up-regulated by nebivolol which are down-regulated
by atenolol (N2 control here also representing non-treated controls). Keywords: Atenolol,
hypoxia,
Nebivolol
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34. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Atenolol - Nebivolol
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
Panels A und B show all genes regulated by either atenolol or nebivolol under non-ischemic, well-oxygenated conditions. Panel
A (red) summarizes all genes down-regulated by nebivolol compared to those up-regulated by atenolol during normoxia. Hence, panel A demonstrates the direct influence of atenolol and nebivolol
on gene expression in well-oxygenated preparations. It can easily be seen that, under optimal conditions, without any sign of ischemia/hypoxia, the effect of nebivolol upon gene expression is quite different
from that of atenolol. O2 control indicates gene expression in well-oxygenated preparations without betablockers. O2 nebivolol indicates gene expression in the presence of nebivolol in non-ischemic,
well-oxygenated preparations. The red and green lines indicate the direction of gene regulation. On the left side of panel A, O2 atenolol represents genes differentially expressed under atenolol during control
conditions. Panel B, accordingly, shows all genes up-regulated by nebivolol which are down-regulated by atenolol (O2 control here also representing untreated controls). Keywords: Atenolol,
Nebivolol
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35. Gasser R;
Ablasser K;
Roessl U;
Kraigher-Krainer E;
Lewinski D;
Mangge H;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH;
Udermann H;
Porta S;
Friehs I;
Scherr E;
Brussee H;
Gasser S
Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium
Micriarray experiments
Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23
Typical results derived from microarray experiments. Light intensities on the microtiter plate reflect gene expression. Keywords: light intensities
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36. Gasser R;
Gasser S;
Ablasser K;
Scherr E;
Roessl U;
Lewinski D;
Mangge H;
Dellacher A;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH
Quantification of GLUT4 Gene Expression in Human Atrial Myocardium of Hypertensive Patients and the Effect of Experimental Ischaemia Thereupon
Expression of GLUT4
Journal of Clinical and Basic Cardiology 2007; 10 (1-4): 1-6
Relative difference in the expression of GLUT4 under ischaemic and non-ischaemic conditions (n = 8; ± SEM) in hypertensive, diabetic and control subjects. Results show slight trends in GLUT4 mRNA expression, however no statistical significance could be seen in either group. Keywords: Diagramm,
flowchart,
GLUT4,
ischaemia,
Ischämie
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37. Gasser R;
Gasser S;
Ablasser K;
Scherr E;
Roessl U;
Lewinski D;
Mangge H;
Dellacher A;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH
Quantification of GLUT4 Gene Expression in Human Atrial Myocardium of Hypertensive Patients and the Effect of Experimental Ischaemia Thereupon
Hypertensive Patients
Journal of Clinical and Basic Cardiology 2007; 10 (1-4): 1-6
Mean ± SEM of the relative myocardial cellular GLUT4 gene expression in the three tested groups displays clearly the lower GLUT4 expression in hypertensive patients directly snap-frozen during cardiac surgery, not equilibrated with 100 % O2. Keywords: Diagramm,
flowchart,
GLUT4,
hypertension,
Hypertonie
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38. Gasser R;
Gasser S;
Ablasser K;
Scherr E;
Roessl U;
Lewinski D;
Mangge H;
Dellacher A;
Mächler H;
Trantina-Yates A;
Tscheliessnigg KH
Quantification of GLUT4 Gene Expression in Human Atrial Myocardium of Hypertensive Patients and the Effect of Experimental Ischaemia Thereupon
GLUT4
Journal of Clinical and Basic Cardiology 2007; 10 (1-4): 1-6
The amount of cycles needed for the amplification curve to exceed the background fluorescence (dashed line) represents the CT value. The quantity of myocardial cellular GLUT4 gene expression is shown as relative difference, which is calculated from the CT values of the housekeeping and the GLUT4 PCR. Keywords: amplification curve,
Amplifikationskurve,
GLUT4
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39. Gasser R;
Gasser S;
Zunko S;
Toferer E
Case Report: Reversible Hyperreninemia Induced by Candesartan in a Young Hypertensive Patient
Plasma renin
Journal für Hypertonie - Austrian Journal of Hypertension 2007; 11 (1): 20-21
Plasma renin in a patient with severe hypertension pre-treated with the ATII receptor candesartan. Arrow indicates discontinuation ("off") and restart
("on") of candesartan treatment (8 mg bid). Keywords: diagram,
Diagramm,
Hypertonie,
plasma renin,
Plasmareninkonzentration
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40. Univ.-Prof. Dr. med. R. Gasser (Innsbruck)
Patient mit Skelettschmerzen und Gangstörung - Fallpräsentation
15. Österreichisches Osteoporoseforum; St. Wolfgang - Salzkammergut; 3.5.2007 - 5.5.2007
Session Nr. 12 - 5.5.2007
Keywords: 15. Österreichisches Osteoporoseforum,
3.-5. Mai 2007,
Digi-vote-System,
Fallbericht,
Mineralstoffwechsel,
Osteoporose
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