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Treffer 11881 - 11920 von 11970 |
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11881. Salvadori A;
Arreghini M;
Bolla G;
Fanari P;
Giacomotti E;
Longhini E;
Miserocchi G;
Palmulli P
Cardiovascular and adrenergic response to exercise in obese subjects
Sauerstoffverbrauch - Adipositas
Journal of Clinical and Basic Cardiology 1999; 2 (2): 229-236
Oxygen consumption (V·O2) vs. watts relationship in nonobese and obese males and females. The regression lines were: V·O2 = 363.6 + 11.4 watt + 91.4Z2 (R2: 0.95; F: 1420; MSE: 10445) in the control group, and V·O2 = 615.3 +/- 12 watt (R2: 0.65; F: 93; MSE: 247.6) in the obese group, with a dummy variable Z2 = 1 for males and 0 for females in the regression line of the normal group because the two regression lines are parallel, but not coincident (p < 0.001). Keywords: Adipositas,
Belastung,
Diagramm,
exercise,
Leistung,
obesity,
oxygen consumption,
Sauerstoffverbrauch
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11882. Boeken U;
Feindt P;
Gams E;
Micek M;
Mohan E;
Petzold Th
The influence of extracorporeal circulation and inflammatory responses such as SIRS and sepsis on secretion of procalcitonin (PCT)
Procalcitoninsekretion
Journal of Clinical and Basic Cardiology 1999; 2 (2): 225-227
Follow-up of PCT-values in group C (sepsis) and D (SIRS) during the postoperative course Keywords: Diagramm,
procalcitonin,
procalcitonin,
sepsis,
sepsis,
SIRS,
SIRS,
systemic inflammatory response syndrome
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11883. Waters J;
Ashford J;
Jäger B;
Verboom CN;
Wonnacott S
Use of moxonidine as initial therapy and in combination in the treatment of essential hypertension - results of the TOPIC (Trial Of Physiotens In Combination) Study
TOPIC-Studie - Design
Journal of Clinical and Basic Cardiology 1999; 2 (2): 219-224
Study plan for TOPIC. A = placebo run-in phase (4 weeks; n = 792). B = open-label monotherapy phase (8 weeks; n = 678; moxonidine 200 mcg/day for 4 weeks, then 200 or 400 mcg/day as required). C = moxonidine monotherapy (4 weeks; n = 303; moxonidine 200 or 400 mcg/day as required for 4 weeks). D, E, F = combination therapy (4 weeks; moxonidine [400 mcg/day] plus other agent as specified below). D = moxonidine plus amlodipine (5 mg/day) (n = 87). E = moxonidine plus enalapril (10 mg/day) (n = 88). F = moxonidine plus hydrochlorothiazide (12.5 mg/day) (n = 97). Keywords: Amlodipin,
amlodipine,
Design,
Design,
Hydrochlorothiazid,
hydrochlorothiazide,
Moxonidin,
moxonidine,
Schema,
Studie,
study,
TOPIC,
TOPIC
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11884. Auer J;
Eber B
Current aspects of statins
Serumcholesterin - KHK-Tod
Journal of Clinical and Basic Cardiology 1999; 2 (2): 203-208
Relationship between serum cholesterol and coronary artery disease mortality rate. Data from the Lipid Research Clinics Program Prevalence Study [49] and in the three major lipid lowering trials in secondary prevention involving statins (triangle) [6, 10, 11]. Keywords: Cholesterin,
cholesterol,
coronary artery disease,
Diagramm,
Koronare Herzkrankheit,
mortality,
Mortalität,
Statin,
Statin
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11885. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Bar graph showing changes in the number and duration of silent ischaemia events with mibefradil treatment. A significant linear dose-response relation is shown across all treatment groups for ischaemic events and ischaemia duration, p < 0.001. Keywords: calcium channel,
Diagramm,
ischaemia,
Ischämie,
Kalziumkanal,
mibefradil,
mibefradil
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11886. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Left panel: Maximal ST-segment depression in mV before (open bars) and 2 hours after (hatched bars) intake of placebo or 50, 100, or 200 mg/kg mibefradil; * p < 0.05. Right panel: Mean exercise duration in minutes before (open bars) and 2 hours after (hatched bars) intake of placebo or 50, 100, or 200 mg/kg mibefradil; * p < 0.05. Keywords: Belastung,
calcium channel,
Diagramm,
exercise,
Kalziumkanal,
mibefradil,
mibefradil,
ST-segment depression,
ST-Segmentsenkung
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11887. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Time courses of blood pressure, heart rate, PQ time, and change of cardiac output on day 1 (left panel) and day 8 (right panel) in patients with hypertension after oral administration of mibefradil given once daily as drinking solution (white circle indicates placebo (PL), triangle indicates 50 mg/kg, black circle indicates 150 mg/kg, square indicates 200 mg/kg mibefradil). Data are shown as mean +/- SEM. Keywords: blood pressure,
Blutdruck,
calcium channel,
cardiac output,
cardiac output,
Diagramm,
heart rate,
Herzfrequenz,
Kalziumkanal,
mibefradil,
mibefradil,
PQ-time,
PQ-Zeit
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11888. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Cumulative percent survival of rats with chronic heart failure, either untreated (circle, n = 68) or treated with mibefradil (15 mg/kg/d, n = 59, white triangle) or cilazapril (10 mg/kg/d, n = 59, black triangle) Keywords: calcium channel,
cilazapril,
cilazapril,
heart failure,
Herzinsuffizienz,
Kalziumkanal,
mibefradil,
mibefradil,
survival,
Überleben
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11889. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Infarct size is given as percentage of left ventricular circumference (%) 6 weeks after induction of myocardial infarction (MI) in rats. Indicated are animals subjected to control MI animals (placebo, black column) and mibefradil-treated animals (10 mg/kg/d p.o.) started at different time points before and after induction of MI (striped columns, 7 d pre, 3 h post, 24 h post, 3 d post, 7 d post). Data represent mean +/- SEM, n = 12-15; * significant versus control MI (p < 0.05). Keywords: calcium channel,
Diagramm,
infarct size,
Infarktgröße,
Kalziumkanal,
left ventricle,
linker Ventrikel,
mibefradil,
mibefradil
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11890. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Cumulative concentration-response curves for the effects of mibefradil, verapamil, and nifedipine on force of contraction in isolated, electrically driven human left ventricular papillary muscle strips. Original records (A) of isometric force of contraction after application of mibefradil (upper) and nifedipine (lower) and a summary of the results (B) are shown. Ordinate in B, force of
contraction in percentage of predrug value. Abscissa in B, concentration of drug (in microM). Number of strips is shown in brackets. Keywords: calcium channel,
contraction force,
Diagramm,
Diltiazem,
Diltiazem,
Felodipin,
felodipine,
Isradipin,
isradipine,
Kalziumkanal,
Kontraktionskraft,
mibefradil,
mibefradil,
Nifedipin,
nifedipine,
Nitrendipin,
nitrendipine,
Verapamil,
Verapamil
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11891. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Effects of verapamil (1 mg/kg i.v.) and mibefradil (3 mg/kg i.v.) on coronary blood flow (CBF) in dogs compared to placebo treated controls. CBF was measured with radioactive microspheres before and 10 min after initiation of drug treatment. Mean +/- SEM, * p<0.05 versus before therapy Keywords: calcium channel,
coronary blood flow,
Diagramm,
Kalziumkanal,
koronarer Blutfluss,
mibefradil,
mibefradil,
Verapamil,
Verapamil
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11892. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Inhibition of proliferation of CPAE cells by mibefradil. Cells were seeded in the absence (sqaure, control) and the presence of (circle) 1 microM, (triangle, peak up) 10 micorM and (triangle, peak down) 100 microM mibefradil. Inhibition of proliferation was significant at all concentrations. At 100 microM no living cells were present, at 10 microM adhesive cells could still be counted indicating true antiproliferative effects. Plotted are mean +/- SEM (vertical lines) at each day after seeding. Keywords: calcium channel,
Diagramm,
Kalziumkanal,
mibefradil,
mibefradil
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11893. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Left panel: Inhibition of volume-activated Cl- currents by mibefradil. a: Activation of the volume-sensitive Cl- current ICl,vol by challenging the cell with a 27 % hypotonic solution. Mibefradil induced a fast and reversible block of ICl,vol. b: At the times indicated, I-V curves were depicted. Reversal potential was approximately at the expected ECl= -16 mV. c: Concentrationresponse curve of the inhibitory action of mibefradil on ICl,vol. Right panel: High-affinity block of Ca2+ activated Cl- channels by mibefradil. a: A CPAE cell was loaded with a Ca2+-solution buffered at 500 nM after breaking the membrane. Elevation of [Ca2+]i activated a Cl- current ICl,Ca. This current was probed by application of voltage ramps. From these ramps, the current can be measured at any potential. Shown is the current activation at +100 mV. Application of 10 microM mibefradil induced a fast and reversible block of ICl,Ca. b: At the times indicated in A, I-V curves were depicted; 1) shows the fully activated Cl- current, 2) the blocked current after application of mibefradil. c: Concentration-response curve of the inhibitory action of mibefradil. Keywords: calcium channel,
Diagramm,
Kalziumkanal,
mibefradil,
mibefradil
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11894. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Concentration-response curve for the action of mibefradil on vascular muscle Ca2+ currents shows that the actions are more efficacious on T-type currents (T, black triangle, peak up). L indicates L-type currents (black triangle, peak down). Black square indicates L- and T-type currents. These percent inhibitions are based on reductions of the Ba2+ current (IBa) as shown in figure 3, corresponding T to figure 3A, L to figure 3B, and L and T to figure 3C. Data represent mean +/- SEM for 6 to 16 cells at each concentration. Keywords: Diagramm,
L-Typ-Kalziumkanal,
L-type calcium channel,
mibefradil,
mibefradil,
T-Typ-Kalziumkanal,
T-type calcium channel
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11895. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Mibefradil
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Effects of 1 micromol/l mibefradil on T-type (A), L-type (B), and composite (C) Ba2+ current (IBa). (o conforms control group, black square conforms 1 microM mibefradil treated group). A: T-type IBa (VT= -20 mV from VH= -80 mV) was 80 % inhibited after 5 minutes by 1 micromol/l mibefradil. B: L-type IBa (VT= +20 mV from VH= -30 mV) was reduced by only 28 % after 8 minutes in 1 micromol/l mibefradil. C: The T-type peak and the same 28 % of L-type IBa as in B were blocked at 5 minutes by 1 micromol/l mibefradil (VT= +20 mV from VH= -80 mV). All tracings are from the same vascular muscle cell. Keywords: Diagramm,
L-Typ-Kalziumkanal,
L-type calcium channel,
mibefradil,
mibefradil,
T-Typ-Kalziumkanal,
T-type calcium channel
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11896. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
L-Typ-Kalziumkanal - Medikamenteninteraktion
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Schematic overview of the drug interaction sites of the CCA (dihydropyridines, diltiazem, verapamil, fantofarone, mibefradil) with the L-type calcium channel Keywords: Dihydropyridin,
dihydropyridines,
Diltiazem,
Diltiazem,
Fantofaron,
fantofarone,
L-Typ-Kalziumkanal,
L-type calcium channel,
mibefradil,
mibefradil,
Schema,
Verapamil,
Verapamil
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11897. Sandmann S;
Unger T
L- and T-type calcium channel blockade - the efficacy of the calcium channel antagonist mibefradil
Kalziumkanal - Alpha-1-Einheit
Journal of Clinical and Basic Cardiology 1999; 2 (2): 187-201
Schematic representation of the α1 unit of the calcium channel with its structural composition of subunits I-IV and segments S1-S6, and the functional importance of the several components Keywords: alpha-1-unit,
calcium channel,
Kalziumkanal,
Schema
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11898. Gasser R;
Klein W;
Köppel H
Lercanidipine, a new third generation Ca-antagonist in the treatment of hypertension
Lercanidipin - systolischer und diastolischer Blutdruck
Journal of Clinical and Basic Cardiology 1999; 2 (2): 169-174
Mean supine systolic and diastolic blood pressure and heart rate at baseline and after 30, 60 and 90 days treatment with lercanidipine 20-40 mg once (n = 16; diamonds) or twice daily (n = 20; squares) (redrawn according to [46]) Keywords: Diagramm,
diastolic blood pressure,
diastolischer Blutdruck,
Lercanidipin,
lercanidipine,
systolic blood pressure,
systolischer Blutdruck
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11899. Gasser R;
Klein W;
Köppel H
Lercanidipine, a new third generation Ca-antagonist in the treatment of hypertension
Lercandipin - systolischer Blutdruck
Journal of Clinical and Basic Cardiology 1999; 2 (2): 169-174
Mean decrease in systolic blood pressure (SBP) after 4 weeks of treatment as seen by Circo in 132 patients (redrawn according to [37]; grey: 24 +/- 2 hours post-dose; black: 4-5 hours post-dose) Keywords: blood pressure,
Diagramm,
Lercanidipin,
lercanidipine,
systolischer Blutdruck
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11900. Houston RJF;
Oeseburg B;
Skotnicki SH;
Verheugt FWA;
Zeebregts CJAM
Adenosine added to cardioplegic solution at low dose reduces functional recovery after normothermic ischaemia in isolated rat heart
Dostinex(R)
Journal of Clinical and Basic Cardiology 1999; 2 (1): 110-112
Keywords: Cabergolin,
Dostinex,
Indikation
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11901. Houston RJF;
Oeseburg B;
Skotnicki SH;
Verheugt FWA;
Zeebregts CJAM
Adenosine added to cardioplegic solution at low dose reduces functional recovery after normothermic ischaemia in isolated rat heart
Norprolac(R) - Quinagolid
Journal of Clinical and Basic Cardiology 1999; 2 (1): 110-112
Keywords: Indikation
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11902. Rakovec P;
Fettich JJ;
Fidler V;
Prepadnik M;
Rode P
Contraction sequence in ventricular tachycardia
Ventrikuläre Tachykardie
Journal of Clinical and Basic Cardiology 1999; 2 (1): 134
Radionuclide phase imaging; details: see text Keywords: tachycardia,
Tachykardie,
ventricle,
Ventrikel
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11904. Kohn P;
Chnupa P;
Fischer V;
Motovska Z
Uncommon case of embolising pseudomyxoma of both atria
Pseudomyxom in beiden Atrien
Journal of Clinical and Basic Cardiology 1999; 2 (1): 132-133
Transesophageal echocardiography: Pseudomyxoma in the right and left atrium Keywords: Atrium,
Atrium,
echocardiography,
Echokardiographie,
Pseudomyxom,
pseudomyxoma
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11905. Kisters K;
Dietl KH;
Krefting ER;
Rahn KH;
Senninger N;
Westermann GW
Intracellular Mg++ concentrations in vascular smooth muscle cells and heart muscle cells in spontaneously hypertensive rats
Aorta - Intrazelluläres Magnesium
Journal of Clinical and Basic Cardiology 1999; 2 (1): 120-122
Intracellular magnesium ion content in aortic smooth muscle cells from normotensive rats (WKY) and SHR (means +/- SD, p < 0.05) Keywords: Aorta,
Aorta,
Diagramm,
Glatte Muskelzelle,
magnesium,
magnesium,
smooth muscle cell
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11906. Kisters K;
Dietl KH;
Krefting ER;
Rahn KH;
Senninger N;
Westermann GW
Intracellular Mg++ concentrations in vascular smooth muscle cells and heart muscle cells in spontaneously hypertensive rats
Gefrierschnitt linker Ventrikel
Journal of Clinical and Basic Cardiology 1999; 2 (1): 120-122
Cryosection of the left ventricle from a spontaneously hypertensive rat showing striated muscle cells (about 4 µm length) Keywords: cryosection,
Gefrierschnitt,
Gestreifte Muskelzelle,
Histologisches Präparat,
histology,
hypertension,
Hypertonie,
left vetricle,
linker Ventrikel,
striated muscle cell
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11907. Kisters K;
Dietl KH;
Krefting ER;
Rahn KH;
Senninger N;
Westermann GW
Intracellular Mg++ concentrations in vascular smooth muscle cells and heart muscle cells in spontaneously hypertensive rats
Gefrierschnitt Aorta
Journal of Clinical and Basic Cardiology 1999; 2 (1): 120-122
Cryosection of rat aorta of about 3 µm length showing vascular smooth muscle cells (white arrows) Keywords: Aorta,
Aorta,
cryosection,
Gefrierschnitt,
Glatte Muskelzelle,
Histologisches Präparat,
histology,
smooth muscle cell
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11908. Zehetgruber M;
Berger R;
Christ G;
Huber K;
Kostner K;
Mundigler G;
Neunteufl T
Basal and stimulated release of long-acting EDRF by bovine pulmonary arteries
Pulmonalarterie - Relaxation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 117-119
Relaxation of bovine pulmonary arteries under stimulated conditions. A: Representative tracing. In the upper panel significant relaxation was induced by perfusing the detector with effluent of an endothelium intact pulmonary artery (generator) which was collected and stored prior to perfusion for five minutes (CE). Addition of acetylcholine (ACh 10-6 M) to the perfusion medium of the generator (CE-ACh) augmented relaxation.
Following direct superfusion (G-ACh), relaxation was more pronounced. In control experiments (lower panel) only direct superfusion was performed; W = wash. B: Average relaxation. Keywords: Arteria pulmonalis,
Arteria pulmonalis,
Diagramm,
EDRF,
EDRF,
Endothel,
endothelium,
Relaxation,
Relaxation
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11909. Zehetgruber M;
Berger R;
Christ G;
Huber K;
Kostner K;
Mundigler G;
Neunteufl T
Basal and stimulated release of long-acting EDRF by bovine pulmonary arteries
Pulmonalarterie - Relaxation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 117-119
Relaxation of bovine pulmonary arteries under basal conditions. A: Representative tracing. Endothelium deprived artery strip (detector) was precontracted with 10-5 M histamine (HA). In the upper panel significant relaxation was induced by perfusing the detector with effluent of an endothelium intact pulmonary artery (generator) which was collected and stored prior to perfusion for
five minutes (CE). Following direct superfusion (G), additional relaxation was induced. In control experiments (lower panel) only direct superfusion (G) was performed; W = wash. B: Average
relaxation. Data shown as mean +/- SEM. Keywords: Arteria pulmonalis,
Arteria pulmonalis,
Diagramm,
EDRF,
EDRF,
Endothel,
endothelium,
Relaxation,
Relaxation
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11910. Sabbah HN;
Goldstein S;
Sharov VG
Remodeling of the cardiac interstitium in the progression of heart failure
Herzinsuffizienz - Progression
Journal of Clinical and Basic Cardiology 1999; 2 (1): 113-116
Bar graph (mean +/- SEM) depicting changes in volume fraction of reactive interstitial fibrosis (RIF), capillary density (C/F Ratio), oxygen diffusion distance (ODD) and average myocyte cross-sectional area (MCSA) in LV myocardium of normal dogs (NL), dogs with heart failure (CHF) sacrificed at 2 weeks (2w) and 4 months (4m) after the last embolization. *= p < 0.05 2w vs. 4m Keywords: Diagramm,
heart failure,
Herzinsuffizienz,
Progression,
Progression
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11911. Houston RJF;
Oeseburg B;
Skotnicki SH;
Verheugt FWA;
Zeebregts CJAM
Adenosine added to cardioplegic solution at low dose reduces functional recovery after normothermic ischaemia in isolated rat heart
Linksventrikuläre Auswurffraktion - Ischämie
Journal of Clinical and Basic Cardiology 1999; 2 (1): 110-112
Left ventricular output normalized to 100 % at start of pre-ischaemic assessment (Pre 1). Hearts were stable for 20 min (until Pre 2). Functional recovery of adenosine-treated hearts (n = 5, dark bars) was less than that of control hearts (n = 5, grey bars) at start (Post 1) and end (Post 2) of assessment (* p < 0.05). Decline in performance of adenosine-treated hearts tended to be more rapid. Standard error of mean shown. Keywords: Diagramm,
ischaemia,
Ischämie,
left ventricular ejection fraction,
linksventrikuläre Auswurffraktion
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11912. Houston RJF;
Oeseburg B;
Skotnicki SH;
Verheugt FWA;
Zeebregts CJAM
Adenosine added to cardioplegic solution at low dose reduces functional recovery after normothermic ischaemia in isolated rat heart
Linksventrikuläre Auswurffraktion - Ischämie
Journal of Clinical and Basic Cardiology 1999; 2 (1): 110-112
Experimental protocol. Left ventricular output reported during 5 min intervals (shaded boxes indicated at top of assessment period). "Switch" interval: switch from working to Langendorff, set up and flush infusion pump. (Second switch interval not needed, pump simply turned off.) Keywords: Design,
experimental protocol,
ischaemia,
Ischämie,
left ventricular ejection fraction,
linksventrikuläre Auswurffraktion,
Schema
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11913. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Ultrastructural morphometry (4500x). A: longitudinal section of control rat heart subjected to 20 min. ischaemia and reperfusion; interstitial and interfibrils oedema, severe mitochondria damage and endothelial lesions are detected. B: effect of DPCPX 100 nM: a significant reduction of ultrastructural damage is reported. M: mitochondria, ISE: interstitial oedema, IFE: nterfibrils oedema, E: endothelium. Keywords: Adenosin,
adenosine,
Histologisches Präparat,
histology,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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11914. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Histological samples (200x, fluorescent light) showing the FITC-albumin diffusion. A: control heart submitted to 20 min global ischaemia, B) effect of 100 nm DPCPX: a significant reduction of perivascular (PV, left) and perimyocytic (PM, right) fluorescence is detected. Keywords: Adenosin,
adenosine,
Histologisches Präparat,
histology,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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11915. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Effects of DPCPX on microvascular permeability. Quantitative assessment of FITC-albumin extravasation expressed as IOI (integrated optical intensity; see Material and methods) units; data are expressed as mean and SD. * = p < 0.02 vs. KH. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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11916. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Purine release (nmol x min-1 x gr.dw-1). Time course of nucleosides (adenosine, inosine) and metabolites (hypoxanthine and uric acid) in all groups. Data are expressed as mean and SD. * = p = 0.05; ** = p < 0.001. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation,
Purin,
purine
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11917. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Time course of coronary flow (CF: ml/min) in nonischaemic hearts (top) and after 10 (middle) and 20 min. (bottom) ischaemia. Data are expressed as mean and SD; * = p < 0.01 vs. KH perfusion. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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11918. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Heart weight changes: wet weight/dry weight (ww/dw) in all experimental groups. Data are expressed as mean and SD: * = p < 0.01 vs. KH perfused hearts. Keywords: Adenosin,
adenosine,
Diagramm,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation
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11919. Di Napoli P;
Barsotti A;
Contegiacomo G;
Di Iorio P;
Di Muzio M;
Giuliani P;
Maggi A;
Statile D;
Taccardi AA
Effects of A1 adenosine receptor antagonism against ischaemia-reperfusion damage and coronary microcirculation in isolated working rat hearts
Adenosin und koronare Mikrozirkulation
Journal of Clinical and Basic Cardiology 1999; 2 (1): 99-104
Experimental protocol Keywords: Adenosin,
adenosine,
Design,
ischaemia,
Ischämie,
microcirculation,
Mikrozirkulation,
Schema
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11920. Holzmann S;
Dittrich P;
Pöch G
Dose-response curves of vasorelaxants: computerized calculation of combination effects using the example of nicorandil
Dosiswirkungsbeziehung - Cromakalim
Journal of Clinical and Basic Cardiology 1999; 2 (1): 96-98
Cumulative dose-response curves (DRCs) of cromakalim in the absence (open symbol) and presence of 10 and 50 micromol/L nicorandil (filled symbols), a) in the absence, b) in the presence of 10 micromol/L methylene blue analogous to Figure 1. The symbols and bars represent experimental mean values from 6-12 experiments and 95 % Cl. The following theoretical curves are shown in a) bands of 95 % CI of dose-additive effects of cromakalim in the presence of 10 micromol/L nicorandil, means of independent effects of cromakalim in the presence of 10 and 50 micromol/L nicorandil, b) 95 % CI bands of dose-additive combinations of cromakalim in the presence of 10 and 50 micromol/L nicorandil. Keywords: Cromakalim,
Cromakalim,
Diagramm,
Methylenblau,
methylene blue,
Nicorandil,
Nicorandil,
vasorelaxation,
vasorelaxation
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