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3961. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Estrogen metabolism in endometrial lesions
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Estrogen metabolism in endometrial lesions: Defective 17-beta-steroid-dehydrogenase type 2. This means that the bioactive estradiol cannot be converted into the less active estron. In the normal endometrium, progesterone activates this 17-beta-HSD Type 2 and has an antiproliferative effect; this mechanism is disrupted in endometrial lesions (so-called progesterone block). Keywords: endometrial lesion,
estrogen metabolism
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3962. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Peritoneal endometriosis
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Various types of peritoneal endometriosis. (a): vesicular form (V); (b): nodular (N) und plaque-type growth (Pl); (c): flat, fibrotic form (F); (d): clear vesicles, no bleeding (B); (e): blood-containing vesicles with flame-shaped inflammation (E); (f): brown, grey residual blood with delicate adhesions (A). Keywords: peritoneal endometriosis,
types
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3963. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Endocrinically active endometriosis
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Microscopic image of endocrinically active endometriosis of the appendix (E = intramural endometrial focus; M = mucous membrane of the appendix). (a): highly differentiated, proliferative endometrial foci (HE stain, 200 ); (b): highly positive estrogen receptors (ERp, brown stain, 200 l). Keywords: appendicitis,
endometriosis,
salpingitis
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3964. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Endoscopic appearance of endometriosis
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Endoscopic appearance of endometriosis. (a): fresh peritoneal endometrial lesion on the pelvic peritoneum with distinctly visible vessels (Rimbach/Saarlouis); (b): Older, nodular peritoneal endometriosis in the area of the lig. sacrouterinum (Rimbach/Saarlouis); (c): Endometriosis in the area of the tube wall with peritubal adhesions (Rimbach/Saarlouis); (d): Conglomerate of appendix and tube in endometriosis: The infundibulum and the inflamed appendix stick together, mixed with vesicular, partially bloody endometriosis (Endo). Keywords: endometriosis,
macroscopic manifestation
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3965. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Chronic abdominal pain
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Share of endometriosis as a cause of chronic abdominal pain. Mod. from [34]. Keywords: abdominal pain,
endometriosis
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3966. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Practical Recommendation
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Practical approach to work up dysmenorrhea and cyclic abdominal pain. Keywords: abdominal pain,
dysmenorrhea,
Laparoscopy
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3967. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Ovarian endometriosis
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Cystic ovarian endometriosis with varying activity – ranging from inactive, resting to complex hyperplasia. (a): Cyst wall with clustered, dilated glands (HE, 12,5 ×); (b): Upon larger magnification, the same sample shows the resting epithelium of an endometrioma (HE, 200 ×); (c): Cyst wall with actively proliferating, epithelial lining (HE, 12,5 ×); (d): The same sample in a larger magnification shows the highly prismatic, proliferative epithelium with secretion phenomena (HE, 200 ×); (e): Lining of the cyst wall in ovarian endometriosis with pronounced proliferation (HE, 40 ×); (f): The proliferative activity with areas of simple hyperplasia can also be seen in the cystically dilated glands (HE, 40 ×); (g): Complex hyperplasia of the epithelial lining in cystic ovarian endometriosis (HE, 40 ×); (h): The same sample with CD stain (CD-10, 40 ×). Keywords: cyst wall,
endometriosis
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3968. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Adenocarcinoma
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
(a): Small-cell adenocarcinoma (CC) in the cyst wall of ovarian endometriosis [EM] (HE stain, magnification 12.5 ); (b): Highly prismatic epithelium lining the endometrial cyst of the ovary [EM]; next to it in the same ovary, a clear-cell adenomcarcinoma [CC] (HE stain, magnification 200 ) Keywords: adenocarcinoma,
clear-cell,
ovary,
small-cell
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3969. Rabe T;
Ahrendt HJ;
Albring C;
Bitzer J;
Bouchard P;
Cirkel U;
Egarter C;
Knig K;
Harlfinger W;
Matzko M;
Mueck AO;
Rmer T;
Schollmeyer T;
Sinn P;
Strowitzki T;
Tinneberg HR;
Wallwiener M;
DeWilde RL
Ulipristal Acetate for Symptomatic Uterine Fibroids and Myoma-Related Hypermenorrhea Joint Statement by the German Society for Gynecological Endocrinology and Reproductive Medicine (DGGEF) and the German Professional Association of Gynecologists (BVF)
Progesterone receptor modulators
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 82-101
Progesterone receptor modulators – (most important) structural formulas. Keywords: myoma therapy,
progesterone
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3970. von Wolff M;
Lawrenz B
FertiPROTEKT – Network for Fertility Preservation Techniques before Chemo- & Radiotherapy
Treatment recommendation
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 60-65
Treatment recommendation – Hodgkin’s Lymphoma Keywords: Hodgkins lymhoma,
treatment
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3971. von Wolff M;
Lawrenz B
FertiPROTEKT – Network for Fertility Preservation Techniques before Chemo- & Radiotherapy
Treatment recommendation
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 60-65
Treatment recommendation – Breast cancer. Keywords: breast cancer,
treatment
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3972. von Wolff M;
Lawrenz B
FertiPROTEKT – Network for Fertility Preservation Techniques before Chemo- & Radiotherapy
FertiPROTEKT website hits
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 60-65
Annual number of “hits” on the Ferti PROTEKT network German and English language websites. Keywords: FertiPROTEKT
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3973. Schmidt KT;
Ernst E;
Greve T;
Andersen CY
Transplantation of Frozen Thawed Ovarian Tissue – State of the Art
Concentration of FSH
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 55-58
Mean concentration of FSH (IU/L) SEM following transplantation of frozen/thawed ovarian tissue to 15 Danish women. Keywords: FSH
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3974. Schmidt KT;
Ernst E;
Greve T;
Andersen CY
Transplantation of Frozen Thawed Ovarian Tissue – State of the Art
Spontaneous follicular development
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 55-58
Spontaneous follicular development from the first graft site in a peritoneal pocket at the pelvic wall above the internal iliac artery. Keywords: follicle
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3975. Vanderzwalmen P;
Zech NH;
Nagy ZP;
Stecher A;
Papatheodorou P;
Schuff M;
Wirleitner B
Cryopreservation of Human Unfertilized and Fertilized Oocytes
Warming process
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 45-54
Low warming rates and intracellular formation of ice crystals. Warming process from (A) a vitrified state; (B) devitrification; (C) freezing; (D) re-crystallization; (E) thawing. Keywords: vitrification,
warming process
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3976. Vanderzwalmen P;
Zech NH;
Nagy ZP;
Stecher A;
Papatheodorou P;
Schuff M;
Wirleitner B
Cryopreservation of Human Unfertilized and Fertilized Oocytes
Vitrification procedure
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 45-54
Vitrification procedure with the Vitrisafe plug (1). The biological material is placed on the gutter of the
Vitrisafe plug (2). The Vitrisafe plug is inserted into the high security straw (3). Thermo-sealing of the outer straw (4). Hermetically closed vitrification straw (5). Plunged into liquid nitrogen (LN2) Keywords: vitrification,
Vitrisafe
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3977. Vanderzwalmen P;
Zech NH;
Nagy ZP;
Stecher A;
Papatheodorou P;
Schuff M;
Wirleitner B
Cryopreservation of Human Unfertilized and Fertilized Oocytes
Device for aseptic vitrification
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 45-54
Device for aseptic vitrification. The Vitrisafe carrier device consists of the carrier (Vitrisafe plug) (A) and a high security straw 0.3 m (B). G: Gutter to place embryos; B: Aseptic Vitrisafe CBS Straw; C: Aseptic sealed Vitrisafe device; D: Welding points. Keywords: vitrification,
Vitrisafe
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3978. Vanderzwalmen P;
Zech NH;
Nagy ZP;
Stecher A;
Papatheodorou P;
Schuff M;
Wirleitner B
Cryopreservation of Human Unfertilized and Fertilized Oocytes
Vitrification in open and closed devices
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 45-54
Vitrification in open and closed devices following contact with sterile or non-sterile liquid nitrogen (LN2). Keywords: closed system,
LN2,
open system,
vitrification
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3979. Vanderzwalmen P;
Zech NH;
Nagy ZP;
Stecher A;
Papatheodorou P;
Schuff M;
Wirleitner B
Cryopreservation of Human Unfertilized and Fertilized Oocytes
Exposure Steps CPs
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 45-54
Exposure to the CPs for vitrification and to sucrose solutions for warming of MII oocytes and zygotes. EG: ethylene glycol; DMSO: Dimethylsulfoxide Keywords: CPs,
cryoprotectant solutions,
MII Oocyte,
Zygote
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3980. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
Array CGH profile
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
Array CGH profile of a balanced, euploid trophectoderm sample (TE3) of the same cycle. Keywords: array CGH,
euploid
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3981. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
Array CGH profile
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
Array CGH profile of an aneuploid (trisomy 18) of another trophectoderm sample (TE2) of the same cycle. Keywords: aneuploid,
array CGH
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3982. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
Array CGH profile
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
Array CGH profile of an unbalanced rearrangement of chromosomes 7 and 12 after PGD of a trophectoderm sample (TE1). Keywords: array-CGH
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3983. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
PGD for Spinal Muscular Atrophy, SMA
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
PGD for Spinal Muscular Atrophy, SMA. Pedigree illustrating allele sizes of two microsatellite markers
linked to SMN1 and SMN2. Blue and green alleles are linked to the mutation, the orange and red ones to the wild type. Keywords: PGD,
SMA
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3984. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
PGD for Spinal Muscular Atrophy, SMA
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
PGD for Spinal Muscular Atrophy, SMA. DNA sequence analysis for amplification products of exon 7 in mother, father, affected son and two trophectoderm biopsies (TE1, TE2). The mother and father are heterozygous for the nucleotide (C or T) in exon 7 corresponding to the presence of gene copies of SMN1 and SMN2. The son shows only the T-nucleotide of the SMN2 gene and thus carries a homozygous deletion in SMN1. Both TE samples show both nucleotides at this base position, indicating that the blastocysts are either wild type or heterozygous carriers of the deletion. Keywords: PGD,
SMA
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3985. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
PGD for Spinal Muscular Atrophy, SMA
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
PGD for Spinal Muscular Atrophy, SMA. Fragment length analysis for multiplex-PCR products of two polymorphic markers generated from DNA of two trophectoderm biopsies (TE1, TE2). Arrows indicate the alleles linked to the mutation. The TE1 sample shows no alleles linked to the mutation, therefore the corresponding embryo is unaffected. TE2 shows one allele linked to the mutation and one allele linked to the wild type, respectively. This embryo is a heterozygous carrier of the mutation. Keywords: PGD,
SMA
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3986. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
Polar body diagnosis of haemophilia A
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
Polar body diagnosis of haemophilia A: The pedigree shows PCR product sizes (in bp) of five polymorphic markers linked to the F8 gene. Red PCR products are linked to the mutation, green and blue ones are linked to the wild type. As an example, the result of the fragment length analysis is shown for an affected oocyte indicated by the result of PB I (blue) and PB II (red). Keywords: haemophilia A,
PCR,
PGD,
polymorphic markers
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3987. Koehler U;
Schoen U;
Mayer V;
Holinski-Feder E
Preimplantation Genetic Diagnosis for Monogenic Disorders and Chromosomal Rearrangements – The German Perspective
Polar body diagnosis for haemophilia A
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 38-44
Polar body diagnosis for haemophilia A: fragment length analysis of amplified polymorphic markers of
the carrier mother and of PB I and PB II. Arrows indicate polymorphic marker alleles linked to the mutation. The detection of the wild type haplotype in PB I and the haplotype linked to the mutation in PB II indicates the presence of the mutation in the oocyte. Keywords: haemophilia A,
PGD
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3988. Montag M;
Toth B;
Strowitzki T
New Laboratory Techniques in Reproductive Medicine
Series of time-lapse images
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 33-37
Series of time-lapse images taken from one embryo starting at the 2PN stage (upper left) up to the expanded blastocyst stage (lower right). Images were taken at 19.1, 33.1, 47.1, 70.3, 89.3 and 114.1 hours after ICSI and following transfer this embryo implanted and gave a pregnancy. Analysis of cleavage times and intervals between cleavages allows for subtle differentiation between individual embryos and helps choosing the one with the most synchronous and timed development. Keywords: 2PN stage,
blastocyst stage,
time-lapse
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3989. Montag M;
Toth B;
Strowitzki T
New Laboratory Techniques in Reproductive Medicine
Result of an array-CGH analysis
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 33-37
This example shows the result of an array-CGH analysis of the 1st polar body from an oocyte taken from a patient with a maternal reciprocal translocation 46,XX,t(5;8)(q22;p11.2). The possibility to detect numerical (loss of a chromatid 15 and 16) and structural chromosomal aberrations (gain of a chromatid 8p and loss of a chromatid 5q) by array-CGH is obvious. Reprinted in part with permission from [Montag et al., J Reproduktionsmed Endokrinol 2010; 6: 498–502]. Keywords: array-CGH
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3991. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
Gonadotropins applied in relationship to patient’s age, 2000–2008. Keywords: FSH,
u-hMG
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3992. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
Gonadotropins applied 1998–2008, expressed in cycles (blue ordinate) and ratio between recombinant FSH and u-hMG (orange ordinate). Keywords: FSH,
gonadotropins,
u-hMG
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3993. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
Number of treatment cycles with oocyte retrieval, 1997–2010; a, b, c see text. [3]. Keywords: OPU,
ovum pick up
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3994. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
Clinical pregnancy rate per OPU as a function of the number of the executed cycle in 4 different age classes (≤ 29 years, 30 years–34 years, 35 years–39 years, ≥ 40 years) [1]. Keywords: OPU,
pregnancy rate
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3995. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
Mean number of embryos transferred in IVF and ICSI treatment and after cryopreservation of oocytes in the 2-PN stage, 1997–2009 (blue ordinate); percentage of born triplets in relationship to all children born after ART procedure, 1997–2009 (red ordinate). Keywords: Cryo-ET,
embryo transfer,
ICSI,
IVF
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3996. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
Clinical pregnancy rates in IVF and ICSI treatment in age classes; 2008–2010: ≤ 24 years to 33 years, n = 44.712; 34 years – ≥ 44 years, n= 69.653. Keywords: ICSI,
IVF,
pregnancy rate
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3997. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
ICSI therapy: clinical pregnancy rates by age, 2008–2010, 87.702 cycles with embryo transfer. Keywords: embryo transfer,
ICSI therapy,
pregnancy rate
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3998. Bhler K
The German IVF-Registry – D·I·R
Data collection in IVF
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 29-32
IVF therapy: clinical pregnancy rates by age, 2008–2010, 26.663 cycles with embryo transfer. Keywords: embryo transfer,
IVF therapy,
pregnancy rate
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4000. Zitzmann M;
Behre HM;
Kliesch S
Gonadotropin Treatment in Male Infertility
Effects of gonadotropin therapy
Journal fr Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 23-28
Effects of gonadotropin therapy (see Table 1 for modalities) on spermatogenesis in secondary hypogonadism. Induction of spermatogenesis – time until appearance of first sperm in ejaculate. Keywords: gonadotropin therapy,
hypogonadism,
spermatogenesis
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